Villa Borghese was the opening level in Hitman Silent Assassin. The new location seems like a clear homage with its shape, colour and pool.
This wide view of the original villa shows the full playable area. The new Hitman's villa is in the middle of an entire Italian town.
In a nod to modern tastes the old pool seemed to have been updated to a swanky infinity pool in the new game. It's still just as drowny though.