The T-Abyss virus still exists
What this tells us about RE6: This surviving form of the virus is whats being used by the unnamed enemy of RE6. That would explain how the terrorists are creating previously unseen types of BOWs that are popping up all over the world. And T-Abyss is known for rapidly transforming living tissue, which we saw multiple times in the RE6 trailer.
Jessica is a primary villain in Resident Evil 6
What this tells us about RE6: In the RE6 trailer Chris is incredibly angry at a specific woman and the reason for his outburst is referred to as a personal vendetta. After her history of betraying Chris loyalty for bioterrorists, what other woman would elicit that reaction? Furthermore, why would Capcom spend all this time setting up Jessicas femme fatale persona in RER if youre never going to see her again?
We haven't seen the last of Veltro
What this tells us about RE6: Jessica, who we strongly believe will be a primary antagonist of Resident Evil 6, is seen reading Dantes poem when shes given the T-Abyss. This implies that her secret benefactor in her operation was Veltro or an offshoot of it, a group that could easily be the big bad of RE6. The type of worldwide terrorist panic on display in the reveal trailer is of a similar brand with what Veltro employed, only on a much larger scale.
Other familiar faces from Revelations will return in Resident Evil 6
What this tells us about RE6: Resident Evil doesnt have a big supporting cast, so Capcom needs to build it up with characters youre invested in. After spending all that time with these characters (and with the BSAA playing a huge part in RE6) we think its safe to say some, if not all, of these characters will make an appearance in the next game.
Who does Raymond really work for?
What this tells us about RE6: Raymonds shifting loyalties and striking character design make him a memorable character and one we bet will return. Despite handing Jessica the virus, he doesnt seem to be her partner in the cutscene, instead coming off as a delivery guy. Should Raymond appear in RE6, his loyalty will no doubt be further tested, but will we get the answers we want?
The fun's just getting started
Instead, RER creates a whole new world for Resident Evil, tons of new characters and plot lines that are left dangling by the end. Raymonds cryptic final statement above (said after Jessica predicts future trouble from the BSAA) points players to the future, and the future of Resident Evil is RE6. Capcom left a breadcrumb trail pointing to the plot of their next release, you just have to follow it.
