You'd better be here because you're looking for a way to save Jackie in Cyberpunk 2077, because if you're not, huge spoilers for things that might happen. If you're here by accident, leave now at this point - where all you know is a character may may be in danger, they may not. This is a game about branching choice and narratives so who knows what's possible? We're not going to say anything up here about what might happen to Jackie but we will go into story ruining detail below once we've finished drawing this spoiler warning out as much as possible to make sure no one can get angry they saw a something about a possible event after reading through all this and carrying on.
Still here? Your choice.
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Can you save Jackie in Cyberpunk 2077
One of the early prologue missions, The Heist, sees V and Jackie breaking into a location to steal a mysterious object. It's basically the event that sets up the whole game and completing it brings up the title screen and starts the story proper - which could be several hours in if you've been exploring and hanging out in Night City not realising it's the prologue.
While most of the job goes smoothly, when things take a turn for the worst Jackie takes a bullet and, while he helps you fight your way to freedom, things are clearly not looking good. Eventually you'll reach the car you started the mission and while both of you get away, Jackie dies in the car.
The short and easy answer to whether you can save Jackie in Cyberpunk 2077 is no. Sorry. Jackie's fate is hardwired into the story and there's nothing you can do about it. While there are the appearance of choices in how you play the mission, or the decisions and dialogue you pick, the outcome of Jackie's fate is immutable. If you send Jackie's body back home a lot of later events build on this tragic event, and it's a vital part of the plot for the first few hours after it happens. (However, if you send his bodies to Victor that will more or less be the end of it.)
So, as much as we hate to say it, Jackie is gone and there's no combination of events or choices that will ever change that.
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