Unfortunately, players cannot save Jackie in Cyberpunk 2077 - the character's death is a fixed event during the Heist that no choices can prevent. We'll go into more detail regarding the circumstances below, but Jackie's death is a foundational moment in V's story, and unless the developers put out a hefty, story-switching patch in the future, there's nothing you can do about it. Below we'll go into more detail about the Cyberpunk save Jackie choice - or lack thereof - and why the character won't see the second act, no matter what you do.
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Can you save Jackie in Cyberpunk 2077
One of the early prologue missions, The Heist, sees V and Jackie breaking into a location to steal a mysterious object. It's basically the event that sets up the whole game and completing it brings up the title screen and starts the story proper - which could be several hours in if you've been exploring and hanging out in Night City not realising it's the prologue.
While most of the job goes smoothly, when things take a turn for the worst Jackie takes a bullet and, while he helps you fight your way to freedom, things are clearly not looking good. Eventually you'll reach the car you started the mission and while both of you get away, Jackie dies in the car.
The short and easy answer to whether you can save Jackie in Cyberpunk 2077 is no. Sorry. Jackie's fate is hardwired into the story and there's nothing you can do about it. While there are the appearance of choices in how you play the mission, or the decisions and dialogue you pick, the outcome of Jackie's fate is immutable. If you send Jackie's body back home a lot of later events build on this tragic event, and it's a vital part of the plot for the first few hours after it happens. (However, if you send his bodies to Victor that will more or less be the end of it.)
So, as much as we hate to say it, Jackie is gone and there's no combination of events or choices that will ever change that.
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