The Marvel's Spider-Man 2 Hybrid Calibration puzzle tasks you with modifying plant DNA by rotating hexagons to create a chain of symbols and hit certain Plant Attribute requirements. It's a mandatory part of the Heal the World mission at the Emily-May Foundation, where Harry and Doctor Foster are trying to create special kinds of crops. But this puzzle type comes up a few times over the course of Marvel's Spider-Man 2, so it's good to understand how it works. If you want a gene-splicing 101 class, here's our guide on how to solve the Spider-Man 2 Hybrid puzzle.
How to solve the plant hybrid puzzle in Spider-Man 2
The solutions for all three stages of the Spider-Man 2 hybrid puzzle are above and in order from left to right.
To succeed you need to fulfil the minimum conditions for certain qualities, but it doesn't matter if you go over. For example, note how there are two "leaf" icons in the third puzzle above, despite needing only one, and it's still a successful combination. The lines on the outside of the hexagons determine what each icon can sync up with, so three lines can only click with three lines, etc.
There'll be more puzzles of this type later on, particularly if you pursue the Spider-Man 2 EMF Experiments that unlock later. This mission is basically the tutorial to a longer-lasting gameplay mechanic, so it's worth keeping these puzzle rules in mind for later.
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