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  1. Entertainment
  2. TV
  3. Supernatural Shows
  4. The Boys

The Boys season 5 just demolished The Last of Us franchise with one sentence

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By Fay Watson published 22 April 2026

The Last of Us is canon in The Boys universe

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The Boys season 5
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The Boys season 5 episode 4 looked pretty familiar right? The superhero series went full The Last of Us in the new episode, complete with spores, wall zombies, and infected growths as the gang headed to Vought facility Fort Harmony in search of V-One.

The homage to the legendary franchise even got a reference in the new episode too, but it was a pretty brutal one. From here on out we'll be getting into The Boys season 5 episode 4 spoilers so make sure you're up to date before reading on.

If you're still here then you'll know that as Billy Butcher and the gang approached the mysterious Vought facility, stuff started getting very creepy. Not only were there several of corpses on the path there, but inside Frenchie realizes that the men who died actually killed each other.

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"Toxoplasmosis, it's a parasite in cat shit, it can infect humans. Makes them react with explosive anger," Frenchie explains. "If the V-One spilled into the groundwater, it could mutate the plants. Their spores fill us with rage, we murder each other, and voila, we're plant food for these vines."

Or as Hughie says, "Okay, so like The Last of Us?" While it's definitely what we were all thinking as the camera panned over mutated vines stuck to the walls of the lab, Frenchie had a more cutting response: "No, that is just The Walking Dead with mushrooms." Ouch, talk about destroying a franchise in one sentence…

I mean, he's not entirely wrong either. Both are zombie stories with infection spreading in The Last of Us through fungus... Fans have been loving the tongue-in-cheek quip too, reacting on Reddit to the moment. "Hughie mentioning The Last of Us a second after we all thought of it was lampshading done right," one commented, as another added: "Frenchie just upset the entire The Last of Us fanboys."

For more on all the other Easter eggs and pop culture references, check out our The Boys season 5 episode 4 recap. While you're at it, have a read of our The Boys season 5 release schedule and The Boys season 5 recap to stay up to date too.

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Fay Watson
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Deputy Entertainment Editor

I’m the Deputy Entertainment Editor here at GamesRadar+, covering TV and film for the Total Film and SFX sections online. I previously worked as a Senior Showbiz Reporter and SEO TV reporter at Express Online for three years. I've also written for The Resident magazines and Amateur Photographer, before specializing in entertainment.

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