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Resident Evil 3 vaccine puzzle solution explained

A monster with a huge gun in Resident Evil 3 Nemesis
(Image credit: Capcom)

The Resident Evil 3 vaccine puzzle you encounter in the Remake is one of the last puzzles you'll encounter in the game, based around setting three temperature dials from "low - mid - high" to create the vaccine to the T-Virus, which has been something of an issue across the plot of Resident Evil 3 (opens in new tab). We'll explain how to get the antigen and adjuvant samples necessary and the puzzle solution to setting the temperatures below.

Resident Evil 3 vaccine puzzle: find the antigen and adjuvant samples

In order to make the Resident Evil 3 vaccine at all you'll need to find two different samples and mix them together, an antigen and adjuvant. 

You find the antigen sample in the 2F lab: 

(Image credit: Capcom)

To get it look for a row of three yellow robot arms in glass cabinets and interact with the console in the middle. One of the arms should then fetch the sample for you. 

The adjuvant sample lives in the 2F Incubation Lab: 

(Image credit: Capcom)

The sample will be in a cabinet of glass fronted draws with one green light in a line of red ones. Interact with the draw to get the sample

Resident Evil 3 vaccine puzzle temperature solution

(Image credit: Capcom)

Once you've combined the antigen and adjuvant sample insert them in to the macine you'll find in the main 2F room, here:  

(Image credit: Capcom)

You'll then need to set three different temperature controls between low, mid and high so that all three are green. The solution for that is as shown below: Mid - High - Low.  

Resident Evil 3 vaccine puzzle temperature solution

(Image credit: Capcom)

Once that's done the vaccine will be mixed and you'll be able to continue on with saving Raccoon City. Well, sort of. Feels like there's not much Raccoon City left to save at this point, but a Resident Evil protagonist never let common sense slow them down before, and they're not going to start now.

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Leon Hurley
Leon Hurley

I'm currently GamesRadar's Senior Guides Co-ordinator, which means I've had a hand in producing or writing all of the guide and tips content on the site. I also write reviews, previews and features, and do video. Previously I worked for Kotaku, and the Official PlayStation Magazine and website. I'm a big fan of open world games, horror, and narrative adventures.