Skip to main content
Join The Community
- Join our community
Commenting
Join the discussion
Exclusive Articles Coming Soon
Member-only articles
Weekly Newsletters
Weekly gaming & entertainment news
Member Badges
Earn badges as you go
Exclusive Competitions
Members-only prize draws
Curated Deals Coming Soon
Tech and gaming deals worth grabbing
GET COMMUNITY ACCESS QUICK
For the quickest way to join, simply enter your email below and get access. We will send a confirmation and sign you up to our newsletter to keep you updated on all your gaming news.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.
FIND OUT ABOUT OUR MAGAZINE
Want to subscribe to the magazine? Click the button below to find out more information.
Find out more
GET Community ACCESS QUICK

Join the GamesRadar community for quick access. Enter your email below and we'll send confirmation, and sign you up to our newsletter.

By submitting your information, you confirm you are aged 16 or over, have read our Privacy Policy and agree to the Terms & Conditions. Geographical rules apply.

Welcome to GamesRADAR+ Community !
Hi ,

Your membership journey starts here.

Keep exploring and earning more as a member.

MY ACCOUNT

Earn your first badge
Read 1 article to unlock your first badge.
Keep earning badges
Explore ways to get more involved as a member.
Latest Games News

Latest Games News

Breaking gaming news and updates

Read Now
Latest Games Reviews

Latest Games Reviews

Expert verdicts on the newest releases

Read Now

See what you’ve unlocked.

Explore your membership benefits.

Explore
Member Exclusives

Stay Ahead with GamesRadar+

Get the biggest gaming news, reviews, and releases straight to your inbox.

Explore

Sign Out
GamesRadar+
US EditionUS CA EditionCanada UK EditionUK AU EditionAustralia
Sign in
  • View Profile
  • Sign out
  • Games
    • Game Insights
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
    • Genres
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
    • Franchises
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • Insights
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
    • Computing
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
    • Accessories & Tech
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • Videos
    • GR+ Replay - Submit Your Clips
    • G+RLS Podcast
  • Edge
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
  • Home
  • Games
    • View Games
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • View Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • View Entertainment
    • TV Shows
      • View TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • View Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • View Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • View Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • View Hardware
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • View Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • View Video
    • Videos
    • GR+ Replay - Submit Your Clips
    • G+RLS Podcast
  • Edge
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
Trending
  • Best Netflix Movies
  • Movie Release Dates
  • Best movies on Disney Plus
  • Best Netflix Shows
Your movies and TV digest from the team at GamesRadar+

Bringing all the latest movie news, features, and reviews to your inbox


By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

You are now subscribed

Your newsletter sign-up was successful


Join the club

Get full access to premium articles, exclusive features and a growing list of member rewards.


An account already exists for this email address, please log in.
  1. Entertainment
  2. Movies

30 Most Gruesome Movie Diseases

Features
By Joshua Winning
Published 5 February 2013

Whatta way to go…

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works.

  • Facebook
  • X
  • Pinterest
  • Flipboard
  • Email
Share this article
Join the conversation
Follow us
Add us as a preferred source on Google
Subscribe to our newsletter

Venereal Disease Shivers (1975)

The Disease: Spread by a parasite, this unnamed venereal disease causes the infected to act out in a typically violent manner.

Worse, the disease can be spread during any form of sexual contact, making it just about the worst STI you could ever get.

Most Gruesome Symptoms: Big, bulging boils that pulse with a life all their own. Mmm, sexy.

How Long You’d Last: Depends how devout you are.

Keep it in your pants, and you’ve got a pretty good chance.

Krippin Virus - I Am Legend (2007)

The Disease: Never mess with diseases. That’s what Dr. Alice Krippin (Emma Thompson) did when she genetically engineered a variant of measles as a cure for cancer, which then turned into a lethal virus of epic proportions.

Most Gruesome Symptoms: The Krippin Virus killed 90% of the Earth’s population.

Those it didn’t kill, it transformed into ‘Darkseekers’, vampiric monsters that hunt and kill humans.

How Long You’d Last:
If the Krippin Virus killed you, count yourself lucky – you wouldn’t want to go up against a Darkseeker.

Even Will Smith couldn’t handle them.

Virulent Bacteria Warning Sign (1985)

The Disease: Created in a top secret military lab, this virulent strain of bacteria was intended as a biological weapon.

Except then it got out into the rest of the building, infecting and eventually killing innocent workers.

Most Gruesome Symptoms: The infected suffer not only from the kind of bad skin usually reserved for hormonal teens, but glowy eyes that would be perfect for raving with.

How Long You’d Last:
This thing was meant as a weapon, and boy is it good at its job. Don’t except to see another sunrise.

Latest Videos FromGamesRadar+
Watch full video here:

Bloody Skin Carriers (2009)

The Disease: A virus that’s gone global, the bloody skin disease in Carriers does exactly what it says on the tin – it opens up gory sores in your skin so that you sort of resemble somebody who’s been on the sunbed a bit too long.

Most Gruesome Symptoms: The icky-looking skin sores – small wonder Brian (Chris Pine) abandons his infected girlfriend.

How Long You’d Last:
Not long. You’ll be able to hide it for a while (like Bobby), but in the end, the bruises and rashes will give the game away. Gross.

Bug Virus - The Thaw (2009)

The Disease: A creeping infection that takes control of the body.

The origin of that infection? Bugs that have been hibernating in the frozen carcass of a woolly mammoth.

Most Gruesome Symptoms: Gross ulcers that gradually creep up the body.

Amputation doesn’t help – when Bart’s infected arm is removed, it doesn’t stop the infection’s covetous spread…

How Long You’d Last:
A matter of days.

You may like
  • Cillian Murphy in 28 Days Later The 25 best zombie movies of all time
  • Jacob Elordi as the Creature in Frankenstein The 25 best Netflix horror movies to watch right now
  • The 30 best horror movies of all time: pictures from The Wicker Man, The Shining, The Texas Chain Saw Massacre, and Hereditary. The 30 best horror movies that will haunt you long after the credits roll

Mad Zombie Disease Zombieland (2009)

The Disease : Remember when there was that massive Mad Cow Disease scare?

Well, in Zombieland , that virus mutated into Mad Person Disease before finally becoming Mad Zombie Disease.

Most Gruesome Symptoms: You basically look like a rotting corpse.

Which is pretty much what you are.

How Long You’d Last: If you follow Columbus’ (Jesse Eisenberg) rules, there’s a good chance you won’t get infected at all.

Vampire plague Daybreakers (2009)

The Disease: A plague propagated by a vampire bat transforms much of the human race into vamps – so much so that neck-chewers are now the norm, and humans are the minority.

Most Gruesome Symptoms: Even if a vampire attempts to retain some of its humanity by abstaining from drinking blood, that just makes things worse.

Fail to sate your bloody appetite and you’ll turn into a ‘subsider’, a horrific bat-like monster that’s as far away from human as it’s possible to get.

How Long You’d Last:
If you’re one of the few unaffected by the vampire plague, it’s likely you’ll get gobbled up pretty sharpish.

If you’re now a vampire, you’re laughing all the way to the blood bank.

Your movies and TV digest from the team at GamesRadar+

Subscribe for a weekly digest of the movie and TV news that matters, direct to your inbox. From first-look trailers, interviews, reviews and explainers, we’ve got you covered.

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

Language Pontypool (2008)

The Disease: A virus that has managed to infect the human language, the unnamed disease in Pontypool can only infect you if you say certain words or phrases.

Most Gruesome Symptoms: As the infection spirals out of control, causing erratic behaviour, it sends its victims to the grave in super-gore-soaked fashion by causing them to vomit a fountain of blood before succumbing to death.

How Long You’d Last:
Laurel-Ann (Georgina Reilly) succumbs in mere hours, but this one probably depends on how well you use the English language…

Reaper Virus Doomsday (2008)

The Disease: Breaking out in Scotland, the Reaper virus “spread across Scotland like a common cold” according to the film’s doom-laden opening narration.

And apparently, “there was no stopping it”…

Most Gruesome Symptoms: You’ve seen The Elephant Man , right?

Now imagine him with what looks like puss-filled burn wounds and you’re pretty much there.

How Long You’d Last: Considering it spreads through the rest of Britain pretty sharpish, not long by our estimations.

Possession Disease - [REC] (2007)

The Disease: Completely unbiased when it comes to infecting humans and animals, the Possession Disease is a contagious virus that causes demonic possession.

Anybody got a number for a good bio-exorcist?

Most Gruesome Symptoms:
You basically end up looking like chopped liver and running around with an insatiable lust for blood.

How Long You’d Last: A fair while, so long as you can find a dark room to inhabit and a few humans to snack on.

  • 1
  • 2
  • 3

Current page: Page 2

Prev Page Page 1 Next Page Page 3
Joshua Winning
Social Links Navigation

Josh Winning has worn a lot of hats over the years. Contributing Editor at Total Film, writer for SFX, and senior film writer at the Radio Times. Josh has also penned a novel about mysteries and monsters, is the co-host of a movie podcast, and has a library of pretty phenomenal stories from visiting some of the biggest TV and film sets in the world. He would also like you to know that he "lives for cat videos..." Don't we all, Josh. Don't we all.  

Read more
Cillian Murphy in 28 Days Later
Horror Movies The 25 best zombie movies of all time
 
 
Jacob Elordi as the Creature in Frankenstein
Horror Movies The 25 best Netflix horror movies to watch right now
 
 
The 30 best horror movies of all time: pictures from The Wicker Man, The Shining, The Texas Chain Saw Massacre, and Hereditary.
Horror Movies The 30 best horror movies that will haunt you long after the credits roll
 
 
Austin Abrams as Bryan in Resident Evil
Horror Movies It turns out the Resident Evil movie's most terrifying zombie monster was performed practically
 
 
Final Destination Bloodlines
Streaming Services The 5 best Halloween Horror movies to stream on Netflix, HBO Max, Hulu, and more (October 23-30)
 
 
Aaron Taylor-Johnson and Lily-Rose Depp in Werwulf
Horror Movies Upcoming horror movies releasing in 2026 and beyond
 
 
Latest in Movies
The Suicide Squad
DC Movies James Gunn confuses everyone by confirming The Suicide Squad is "the first canon film in the DCU"
 
 
Batman
DC Movies New DCU Batman "isn't very far away" from being cast and he'll be around the same age as Superman, James Gunn says
 
 
Bloodborne screenshot of The Hunter player-character with their back to us, wielding a bladed in their right hand and an a ranged weapon in their left
Animated Movies Bloodborne movie is "much" further along than a few months ago as mystery director and writer join
 
 
Harley Quinn in The Suicide Squad
DC Movies James Gunn says he's going to "lay down the law" with new podcast on what is and isn't DCU canon in The Suicide Squad
 
 
Ralph Fiennes as President Snow in The Hunger Games: Sunrise on the Reaping
Action Movies Sunrise on the Reaping may end up as the biggest Hunger Games movie ever, as presales track a $100 million plus opening
 
 
Glenn Close in The Hunger Games: Sunrise on the Reaping
Movies The best movies you need to watch in November 2026
 
 
Latest in Features
Phantom Blade Zero warriors
Action RPGs Phantom Blade Zero has the perfect solution to Elden Ring's biggest buzzkill
 
 
Ghost Rider holds Malekith by the throat and forces the Penance Stare upon him
Tabletop Gaming Marvel's newest character was born out of a shared need with Magic: The Gathering's Darkhold Destiny set
 
 
An in-game character model of a Skyborne - a sort of blue-skinned elf - in World of Warcraft: Forever, with the orange GamesRadar+ Big Preview branding
World of Warcraft After 22 years, World of Warcraft: Forever has finally sold me on Blizzard's undying MMO – now I never want to leave
 
 
A collage of GTA Vice City screenshots including Tommy wielding guns and driving cars through the sunny location, with the Countdown to GTA 6 GamesRadar+ branding
Grand Theft Auto Over 20 years later, GTA Vice City is still a role model for the open-world genre
 
 
Grand Theft Auto 6 key art showing Jason and Lucia loading weapons
Grand Theft Auto Grand Theft Auto VI exclusive – The state that never sleeps
 
 
A skyborne - a blue elf-like race - holds her arms out against a cloudy backdrop in a World of Warcraft: Forever cinematic, with the orange GamesRadar+ Big Preview branding
World of Warcraft 8 Reasons why WoW Forever is ensuring the iconic MMO remains immovable
 
 
LATEST ARTICLES
  1. "For those who're asking, yes we delisted Celeste and TowerFall on XBox"
    1
    Celeste dev delists the legendary platformer from Xbox: "We did this to support the BDS boycott"
  2. 2
    James Gunn confuses everyone by confirming The Suicide Squad is "the first canon film in the DCU"
  3. 3
    Call of Duty: Modern Warfare 4 devs nerf one of DMZ's most-hated perks
  4. 4
    Romancing Saga 3's improvisational JRPG battles have finally turned me into a fan
  5. 5
    How to beat Hua, Deadly Betrothed in Phantom Blade Zero

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

Add as a preferred source on Google Add as a preferred source on Google
  • About us
  • Contact Future's experts
  • Terms and conditions
  • Privacy policy
  • Cookies policy
  • Advertise with us
  • Review guidelines
  • Write for us
  • Accessibility statement
  • Careers

© Future US, Inc. Full 7th Floor, 130 West 42nd Street, New York, NY 10036.

Please login or signup to comment

Please wait...