Skip to main content
Join The Community
- Join our community
11
Premium Benefits
24/7
Access Available
21K+
Active Members
Commenting
Join the discussion
Exclusive Articles Coming Soon
Member-only articles
Weekly Newsletters
Weekly gaming & entertainment news
Member Badges
Earn badges as you go
Exclusive Competitions
Members-only prize draws
Curated Deals Coming Soon
Tech and gaming deals worth grabbing
GET COMMUNITY ACCESS QUICK
For the quickest way to join, simply enter your email below and get access. We will send a confirmation and sign you up to our newsletter to keep you updated on all your gaming news.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.
FIND OUT ABOUT OUR MAGAZINE
Want to subscribe to the magazine? Click the button below to find out more information.
Find out more
GET Community ACCESS QUICK

Join the GamesRadar community for quick access. Enter your email below and we'll send confirmation, and sign you up to our newsletter.

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

Background
Welcome to GamesRADAR+ Community !
Hi ,

Your membership journey starts here.

Keep exploring and earning more as a member.

MY ACCOUNT

Badge picture
Earn your first badge
Read 1 article to unlock your first badge.
Keep earning badges
Explore ways to get more involved as a member.
Latest Games News

Latest Games News

Breaking gaming news and updates

Read Now
Latest Games Reviews

Latest Games Reviews

Expert verdicts on the newest releases

Read Now

See what you’ve unlocked.

Explore your membership benefits.

Explore
Member Exclusives

Stay Ahead with GamesRadar+

Get the biggest gaming news, reviews, and releases straight to your inbox.

Explore

Sign Out
GamesRadar+ GamesRadar+
US EditionUS CA EditionCanada UK EditionUK AU EditionAustralia
Sign in
  • View Profile
  • Sign out
  • Games
    • Game Insights
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
    • Genres
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
    • Franchises
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • Marvel Comics
      • DC Comics
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Hardware
    • Insights
      • Hardware News
      • Hardware Reviews
      • Hardware Features
    • Computing
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
    • Accessories & Tech
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Game Deals
    • Tech Deals
    • TV Deals
    • Buying Guides
  • Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
  • home
  • Games
    • View Games
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • View Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • View Entertainment
    • TV Shows
      • View TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • View Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • View Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • View Comics
      • Marvel Comics
      • DC Comics
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Hardware
    • View Hardware
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • View Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • View Deals
    • Game Deals
    • Tech Deals
    • TV Deals
    • Buying Guides
  • Video
    • View Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
Trending
  • Best Netflix Movies
  • Movie Release Dates
  • Best movies on Disney Plus
  • Best Netflix Shows
Don't miss these
Austin Abrams as Bryan in Resident Evil
Horror Movies New Resident Evil movie takes place "on the periphery" of Resident Evil 2, and everything else we learned from the set
Nicholas Galitzine as He-Man in Masters of the Universe
Movies Upcoming movies: The most exciting new movies coming in 2026 and beyond
A close-up shot of Pinhead from Hellraiser
Horror Games Upcoming horror games for 2026 and beyond
Austin Abrams as Bryan in Resident Evil
Horror Movies Resident Evil movie: Everything we know about the new horror adaptation
Dune
Movies Movie release dates 2026: Every major film coming to cinemas and streaming
Resident Evil 4 leon
Horror Movies Resident Evil movie director Zach Cregger reveals the Resident Evil 4 Easter egg he snuck into the trailer
Cillian Murphy as Tommy in Peaky Blinders: The Immortal Man.
Movies The 25 best movies on Netflix to watch right now
Austin Abrams as Bryan in Resident Evil
Horror Movies Weapons star has the night from hell in first trailer for Zach Cregger's Resident Evil movie
Austin Abrams as Bryan in Resident Evil
Horror Movies Upcoming horror movies coming in 2026 and beyond
Adam Scott as Ohm in Hokum
Horror Movies 5 horror movies made by comedy stars to watch after Adam Scott's new scary flick Hokum
Quarantine Zone symptoms
Simulation Games All Quarantine Zone symptoms and how to identify the infected
Jacob Elordi as Heathcliff in Wuthering Heights
Movies 20 best movies on HBO Max to watch right now
A close-up of Leon, frowning in a big black coat, in Resident Evil Requiem
Horror Games The 25 best horror games worth playing in 2026
(L to R) Steven Yeun as Detective Mike Ro, Matt Damon as Lieutenant Dane Dumars, Ben Affleck as Detective Sergeant J.D. Byrne, and Kyle Chandler as DEA Agent Mateo 'Matty' Nix in The Rip.
Action Movies The 25 best Netflix action movies to watch right now
Sonic, Tails, and Knuckles in Sonic 3
Amazon Prime Video The 25 best movies on Prime Video to watch right now
Sign up for the Total Film Newsletter

Bringing all the latest movie news, features, and reviews to your inbox


By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

You are now subscribed

Your newsletter sign-up was successful


Join the club

Get full access to premium articles, exclusive features and a growing list of member rewards.


An account already exists for this email address, please log in.
  1. Entertainment
  2. Movies

30 Most Gruesome Movie Diseases

Features
By Joshua Winning published 5 February 2013

Whatta way to go…

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works.

  • Facebook
  • X
  • Pinterest
  • Flipboard
  • Email
Share this article
Join the conversation
Follow us
Add us as a preferred source on Google
Subscribe to our newsletter

Venereal Disease Shivers (1975)

The Disease: Spread by a parasite, this unnamed venereal disease causes the infected to act out in a typically violent manner.

Worse, the disease can be spread during any form of sexual contact, making it just about the worst STI you could ever get.

Most Gruesome Symptoms: Big, bulging boils that pulse with a life all their own. Mmm, sexy.

How Long You’d Last: Depends how devout you are.

Keep it in your pants, and you’ve got a pretty good chance.

Krippin Virus - I Am Legend (2007)

The Disease: Never mess with diseases. That’s what Dr. Alice Krippin (Emma Thompson) did when she genetically engineered a variant of measles as a cure for cancer, which then turned into a lethal virus of epic proportions.

Most Gruesome Symptoms: The Krippin Virus killed 90% of the Earth’s population.

Those it didn’t kill, it transformed into ‘Darkseekers’, vampiric monsters that hunt and kill humans.

How Long You’d Last:
If the Krippin Virus killed you, count yourself lucky – you wouldn’t want to go up against a Darkseeker.

Even Will Smith couldn’t handle them.

Virulent Bacteria Warning Sign (1985)

The Disease: Created in a top secret military lab, this virulent strain of bacteria was intended as a biological weapon.

Except then it got out into the rest of the building, infecting and eventually killing innocent workers.

Most Gruesome Symptoms: The infected suffer not only from the kind of bad skin usually reserved for hormonal teens, but glowy eyes that would be perfect for raving with.

How Long You’d Last:
This thing was meant as a weapon, and boy is it good at its job. Don’t except to see another sunrise.

Latest Videos From
You may like
  • Jacob Elordi as the Creature in Frankenstein The 25 best Netflix horror movies to watch right now
  • Michael B. Jordan as 'Smoke' and 'Stack' in Ryan Coogler's new vampire horror Sinners From Sinners to The Wailing, get scared with our guide to the best Prime Video horror movies
  • Thomas Jane as David Drayton screaming at the end of The Mist People are debating the darkest horror movie endings and, yep, these will keep you up at night

Bloody Skin Carriers (2009)

The Disease: A virus that’s gone global, the bloody skin disease in Carriers does exactly what it says on the tin – it opens up gory sores in your skin so that you sort of resemble somebody who’s been on the sunbed a bit too long.

Most Gruesome Symptoms: The icky-looking skin sores – small wonder Brian (Chris Pine) abandons his infected girlfriend.

How Long You’d Last:
Not long. You’ll be able to hide it for a while (like Bobby), but in the end, the bruises and rashes will give the game away. Gross.

Bug Virus - The Thaw (2009)

The Disease: A creeping infection that takes control of the body.

The origin of that infection? Bugs that have been hibernating in the frozen carcass of a woolly mammoth.

Most Gruesome Symptoms: Gross ulcers that gradually creep up the body.

Amputation doesn’t help – when Bart’s infected arm is removed, it doesn’t stop the infection’s covetous spread…

How Long You’d Last:
A matter of days.

Mad Zombie Disease Zombieland (2009)

The Disease : Remember when there was that massive Mad Cow Disease scare?

Well, in Zombieland , that virus mutated into Mad Person Disease before finally becoming Mad Zombie Disease.

Most Gruesome Symptoms: You basically look like a rotting corpse.

Which is pretty much what you are.

How Long You’d Last: If you follow Columbus’ (Jesse Eisenberg) rules, there’s a good chance you won’t get infected at all.

Vampire plague Daybreakers (2009)

The Disease: A plague propagated by a vampire bat transforms much of the human race into vamps – so much so that neck-chewers are now the norm, and humans are the minority.

Most Gruesome Symptoms: Even if a vampire attempts to retain some of its humanity by abstaining from drinking blood, that just makes things worse.

Fail to sate your bloody appetite and you’ll turn into a ‘subsider’, a horrific bat-like monster that’s as far away from human as it’s possible to get.

How Long You’d Last:
If you’re one of the few unaffected by the vampire plague, it’s likely you’ll get gobbled up pretty sharpish.

If you’re now a vampire, you’re laughing all the way to the blood bank.

Sign up for the Total Film Newsletter

Bringing all the latest movie news, features, and reviews to your inbox

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

Language Pontypool (2008)

The Disease: A virus that has managed to infect the human language, the unnamed disease in Pontypool can only infect you if you say certain words or phrases.

Most Gruesome Symptoms: As the infection spirals out of control, causing erratic behaviour, it sends its victims to the grave in super-gore-soaked fashion by causing them to vomit a fountain of blood before succumbing to death.

How Long You’d Last:
Laurel-Ann (Georgina Reilly) succumbs in mere hours, but this one probably depends on how well you use the English language…

Reaper Virus Doomsday (2008)

The Disease: Breaking out in Scotland, the Reaper virus “spread across Scotland like a common cold” according to the film’s doom-laden opening narration.

And apparently, “there was no stopping it”…

Most Gruesome Symptoms: You’ve seen The Elephant Man , right?

Now imagine him with what looks like puss-filled burn wounds and you’re pretty much there.

How Long You’d Last: Considering it spreads through the rest of Britain pretty sharpish, not long by our estimations.

Possession Disease - [REC] (2007)

The Disease: Completely unbiased when it comes to infecting humans and animals, the Possession Disease is a contagious virus that causes demonic possession.

Anybody got a number for a good bio-exorcist?

Most Gruesome Symptoms:
You basically end up looking like chopped liver and running around with an insatiable lust for blood.

How Long You’d Last: A fair while, so long as you can find a dark room to inhabit and a few humans to snack on.

  • 1
  • 2
  • 3

Current page: Page 2

Prev Page Page 1 Next Page Page 3
Joshua Winning
Social Links Navigation

Josh Winning has worn a lot of hats over the years. Contributing Editor at Total Film, writer for SFX, and senior film writer at the Radio Times. Josh has also penned a novel about mysteries and monsters, is the co-host of a movie podcast, and has a library of pretty phenomenal stories from visiting some of the biggest TV and film sets in the world. He would also like you to know that he "lives for cat videos..." Don't we all, Josh. Don't we all.  

Read more
Jacob Elordi as the Creature in Frankenstein
Horror Movies The 25 best Netflix horror movies to watch right now
 
 
Michael B. Jordan as 'Smoke' and 'Stack' in Ryan Coogler's new vampire horror Sinners
Amazon Prime Video From Sinners to The Wailing, get scared with our guide to the best Prime Video horror movies
 
 
Thomas Jane as David Drayton screaming at the end of The Mist
Horror Movies People are debating the darkest horror movie endings and, yep, these will keep you up at night
 
 
Cillian Murphy as Tommy in Peaky Blinders: The Immortal Man.
Movies The 25 best movies on Netflix to watch right now
 
 
Resident Evil Requiem On the Radar screenshot of a zombie biting a fire poker with an orange overlay
Resident Evil Resident Evil Requiem is my new favorite Saw movie thanks to one of the most upsetting survival horror levels in history
 
 
Austin Abrams as Bryan in Resident Evil
Horror Movies Upcoming horror movies coming in 2026 and beyond
 
 
Latest in Movies
andy serkis
Fantasy Movies Andy Serkis says he doesn't see a difference between game and movie acting: "Hollywood is using video game engines"
 
 
Pedro Pascal as Din Djarin unmasked in The Mandalorian and Grogu
Star Wars Movies Pedro Pascal wants to keep playing the Mandalorian for as long as the "many bodies we put into the suit can take it"
 
 
Robert Pattinson in The Batman
DC Movies The rumors are true: The Batman 2 is set in winter as Matt Reeves delivers perfect first look
 
 
Idris Elba, Nicholas Galitzine, and Camila Mendes in Masters of the Universe
Adventure Movies New Masters of the Universe TV spot gives us our first glimpse at He-Man riding Battle Cat
 
 
Brendan Fraser in The Mummy
Adventure Movies Brendan Fraser says The Mummy 4 revisits original locations and give fans "what they have been bothering all of us for"
 
 
Katee Sackhoff as Kara "Starbuck" Thrace, aiming a gun, in Battlestar Galactica.
Sci-Fi Shows Paramount Plus just added the best sci-fi show of the 2000s to its library
 
 
Latest in Features
The official Summer Game Fest logo in shades of purples and blues, with a pink circle surrounding the event's title
Games Summer Game Fest 2026 schedule: Dates, times, and where to watch the showcases
 
 
Fox McCloud's rival Falco sitting in the cockpit of an Arwing in a screenshot taken from Star Fox for the Nintendo Switch 2
Nintendo Switch 2 Star Fox 64 remains one of Nintendo's greatest action games, and its Switch 2 remake will prove it to a new generation
 
 
Adeline Rudolph as Kitana in Mortal Kombat 2
Action Movies Mortal Kombat 2 ending explained: who fights, who dies and every fatality
 
 
MTG Secrets of Strixhaven Commander deck and boosters on a wooden table
Tabletop Gaming MTG Secrets of Strixhaven Commander decks, ranked
 
 
An older Makoto wars a hat and glasses, with neon lights behind him in Stranger Than Heaven
Action RPGs Stranger Than Heaven offers the grounded refresh I've been desperate to see from Yakuza RPGs for years
 
 
A picture of Classic Marathon showing the player walking down a corridor in first-person with a gun drawn and a terminal at the other corner
FPS Games I played Marathon and its 1994 predecessor to see how Bungie has evolved over the years
 
 
LATEST ARTICLES
  1. Marathon Triage runner
    1
    Sony reports $765 million impairment loss on Marathon and Destiny 2 studio Bungie for the last financial year
  2. 2
    Homelander star teases his victory in The Boys series finale, and an unused shot from the trailer seems to back it up
  3. 3
    How to unlock the Leon Must Die Forever wolf skin
  4. 4
    Super Mario World director Takashi Tezuka is leaving Nintendo after 42 years
  5. 5
    The Penguin season 2 feels closer than ever to happening thanks to this writer listing

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

Add as a preferred source on Google Add as a preferred source on Google
  • Terms and conditions
  • Contact Future's experts
  • Privacy policy
  • Cookies policy
  • Accessibility statement
  • Careers
  • About us
  • Advertise with us
  • Review guidelines
  • Write for us

© Future US, Inc. Full 7th Floor, 130 West 42nd Street, New York, NY 10036.

Please login or signup to comment

Please wait...