Skip to main content
Join The Community
- Join our community
11
Premium Benefits
24/7
Access Available
21K+
Active Members
Commenting
Join the discussion
Exclusive Articles Coming Soon
Member-only articles
Weekly Newsletters
Weekly gaming & entertainment news
Member Badges
Earn badges as you go
Exclusive Competitions
Members-only prize draws
Curated Deals Coming Soon
Tech and gaming deals worth grabbing
GET COMMUNITY ACCESS QUICK
For the quickest way to join, simply enter your email below and get access. We will send a confirmation and sign you up to our newsletter to keep you updated on all your gaming news.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.
FIND OUT ABOUT OUR MAGAZINE
Want to subscribe to the magazine? Click the button below to find out more information.
Find out more
GET Community ACCESS QUICK

Join the GamesRadar community for quick access. Enter your email below and we'll send confirmation, and sign you up to our newsletter.

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

Background
Welcome to GamesRADAR+ Community !
Hi ,

Your membership journey starts here.

Keep exploring and earning more as a member.

MY ACCOUNT

Badge picture
Earn your first badge
Read 1 article to unlock your first badge.
Keep earning badges
Explore ways to get more involved as a member.
Latest Games News

Latest Games News

Breaking gaming news and updates

Read Now
Latest Games Reviews

Latest Games Reviews

Expert verdicts on the newest releases

Read Now

See what you’ve unlocked.

Explore your membership benefits.

Explore
Member Exclusives

Stay Ahead with GamesRadar+

Get the biggest gaming news, reviews, and releases straight to your inbox.

Explore

Sign Out
GamesRadar+ GamesRadar+
US EditionUS CA EditionCanada UK EditionUK AU EditionAustralia
Sign in
  • View Profile
  • Sign out
  • Games
    • Game Insights
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
    • Genres
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
    • Franchises
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • Insights
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
    • Computing
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
    • Accessories & Tech
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
  • home
  • Games
    • View Games
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • View Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • View Entertainment
    • TV Shows
      • View TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • View Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • View Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • View Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • View Hardware
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • View Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • View Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
Trending
  • Best Netflix Movies
  • Movie Release Dates
  • Best movies on Disney Plus
  • Best Netflix Shows
Don't miss these
Nicholas Galitzine as He-Man in Masters of the Universe
Movies Upcoming movies: The most exciting new movies coming in 2026 and beyond
A close-up shot of Pinhead from Hellraiser
Horror Games Upcoming horror games for 2026 and beyond
Dune
Movies Movie release dates 2026: Every major film coming to cinemas and streaming
Austin Abrams as Bryan in Resident Evil
Horror Movies New Resident Evil movie takes place "on the periphery" of Resident Evil 2, and everything else we learned from the set
Cillian Murphy as Tommy in Peaky Blinders: The Immortal Man.
Movies The 25 best movies on Netflix to watch right now
Austin Abrams as Bryan in Resident Evil
Horror Movies Resident Evil movie: Everything we know about the new horror adaptation
Quarantine Zone symptoms
Simulation Games All Quarantine Zone symptoms and how to identify the infected
A close-up of Leon, frowning in a big black coat, in Resident Evil Requiem
Horror Games The 25 best horror games worth playing in 2026
Austin Abrams as Bryan in Resident Evil
Horror Movies Upcoming horror movies coming in 2026 and beyond
Resident Evil 4 leon
Horror Movies Resident Evil movie director Zach Cregger reveals the Resident Evil 4 Easter egg he snuck into the trailer
Austin Abrams as Bryan in Resident Evil
Horror Movies Weapons star has the night from hell in first trailer for Zach Cregger's Resident Evil movie
(L to R) Steven Yeun as Detective Mike Ro, Matt Damon as Lieutenant Dane Dumars, Ben Affleck as Detective Sergeant J.D. Byrne, and Kyle Chandler as DEA Agent Mateo 'Matty' Nix in The Rip.
Action Movies The 25 best Netflix action movies to watch right now
Sonic, Tails, and Knuckles in Sonic 3
Amazon Prime Video The 25 best movies on Prime Video to watch right now
Jacob Elordi as Heathcliff in Wuthering Heights
Movies 20 best movies on HBO Max to watch right now
Resident Evil 4 Remake screenshot of Leon holding a pistol
Horror Games 10 games like Resident Evil to scare you silly in 2026
Sign up for the Total Film Newsletter

Bringing all the latest movie news, features, and reviews to your inbox


By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

You are now subscribed

Your newsletter sign-up was successful


Join the club

Get full access to premium articles, exclusive features and a growing list of member rewards.


An account already exists for this email address, please log in.
  1. Entertainment
  2. Movies

30 Most Gruesome Movie Diseases

Features
By Joshua Winning published 5 February 2013

Whatta way to go…

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works.

  • Facebook
  • X
  • Pinterest
  • Flipboard
  • Email
Share this article
Join the conversation
Follow us
Add us as a preferred source on Google
Subscribe to our newsletter

Trixie Virus - The Crazies (2010)

The Disease: The Trixie virus, a Rhabdoviridae prototype that was created as a deadly biological weapon.

It gets into the water supply of Ogden Marsh, previously the “friendliest place on Earth”. That’s not quite as true post-epidemic…

Most Gruesome Symptoms: As the title suggests, you get a mad case of the crazies – cue loony eyes and a bloodthirsty desire to hack people to pieces.

How Long You’d Last: Bit pointless to ask; either way you’re screwed.

If you’re infected, you’re done for; if you’re not, you’ll soon have your brains bashed in.

Rat Virus Mulberry Street (2007)

The Disease: It’s every city-dweller’s biggest fear – a virus carried by rats.

That’s a terrifying notion considering that in London alone you’re never more than a few feet away from one of the filthy rodents.

Most Gruesome Symptoms: After being infected, you quickly transform into an evil-looking rat-like creature with a fondness for human flesh.

How Long You’d Last:
Well, let’s put it this way – the virus works so quickly you barely have any time to notice anything’s wrong before realise you suddenly have a tail.

T-Virus - Resident Evil (2002)

The Disease: Created by Dr. Charles Ashford, the T-Virus was originally intended to be a cure for a degenerative disease, but its ability to stimulate pre- and post-mortem cellular growth eventually kills the injectee.

It’s both airborne and transferable by blood, which means you can get infected if an infected person, say, bites you. Lovely.

Most Gruesome Symptoms: Despite killing you, the virus sits in the victim’s brain and reanimates the body – yep, we’re in zombie territory.

How Long You’d Last: It can take as little as three hours for the virus to kill you, then turn you into a zombie.

Latest Videos From
You may like
  • Jacob Elordi as the Creature in Frankenstein The 25 best Netflix horror movies to watch right now
  • Michael B. Jordan as 'Smoke' and 'Stack' in Ryan Coogler's new vampire horror Sinners From Sinners to The Wailing, get scared with our guide to the best Prime Video horror movies
  • Thomas Jane as David Drayton screaming at the end of The Mist People are debating the darkest horror movie endings and, yep, these will keep you up at night

Dino-Virus Carnosaur (1993)

The Disease: Created by Dr. Jane Tiptree (Diane Ladd), the Dino Virus causes infected women to fall pregnant with, yuhuh, baby dinosaurs.

Sounds cute enough, except Tripp wants dinosaurs to reclaim the Earth and wipe out humanity in the process.

Most Gruesome Symptoms: Instead of giving birth conventionally (well, this isn’t exactly a conventional pregnancy), pregnant women are killed as the dinosaur rips itself free Alien -style.

How Long You’d Last: If you’re impregnated, you’re pretty much doomed.

Rage 28 Days Later (2002)

The Disease: A hugely contagious blood-bone virus known only as the ‘Rage’, this disease lives up to its name by turning anybody who’s infected into a raving, ravenous loon.

Most Gruesome Symptoms: Though director Danny Boyle’s adamant this isn’t a horror film, let’s not beat around the bush – we’re definitely dealing with zombies here.

That means the gore-loving infected go rabid and attempt to kill anything that looks like it has a pulse.

How Long You’d Last: Ingesting just a single drop of blood from somebody infected with the Rage can have you vomiting and screaming like a nutter in under a minute.

Better run, eh?

Tenafly Viper - Street Trash (1987)

The Disease: An infection caused by drinking a particularly cheap brand of 60-year-old wine called Tenafly Viper.

A liquor store owner sells it to some homeless people, despite the fact that it’s well past its sell-by date. Dodgy tums all round.

Most Gruesome Symptoms: Quite simply: you turn into an oozy pile of goo.

Ah, we do like a good melting.

How Long You’d Last:
Infection seems to be pretty instantaneous, and there’s no known cure.

Prepare for one heck of a hangover.

Goo Disease Infection (2004)

The Disease: Discovered in an overworked general hospital, this ridiculously messy disease starts out as a black rash before getting altogether gooier…

Most Gruesome Symptoms: First turning you crazy, the virus then liquefies your organs until they resemble little more than a green oozy substance.

You’ll look like you’ve been Slimer-ed.

How Long You’d Last: Not long; within hours of attempting to treat a goo-ified patient, a nurse goes mad, then bleeds green gunk from her eyes and ears.

Sign up for the Total Film Newsletter

Bringing all the latest movie news, features, and reviews to your inbox

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

DC2 Planet Terror (2007)

The Disease: A biochemical agent known both as DC2 and its codename ‘Project Terror’, this gruesome virus is released into a town as gas.

It turns the townspeople into deformed flesh-munchers.

Most Gruesome Symptoms:
The horrific mutations themselves, which range from massive, oozing pustules to burn-like skin problems.

Not nice.

How Long You’d Last:
These guys are pretty damn mean, so unless you’ve got a gun-legged Rose McGowan on your team, it’s unlikely you’ll make it through the night.

Splinter Disease Splinter (2008)

The Disease: A horrific virus that causes spiny, spearing darts to erupt from the body and tear it apart.

Get stuck by a splinter and something really horrible is going to happen to you.

Most Gruesome Symptoms: The splinters are bad enough, but worse still is the way in which a splinter-infected person can Frankenstein’s-monster itself by joining together with other bits of a splinter-infected person.

How Long You’d Last: If you’re unfortunate enough to get a splinter, you have roughly five seconds before it starts to deform your body in horrific, painful ways.

Flesh-Eating Virus - Cabin Fever (2002)

The Disease: Inspired by director-writer Eli Roth’s experiences with a skin infection, Cabin Fever ’s singularly disgusting disease is a flesh-eating virus that’s in the water.

See, the rotting cadaver of an infected hermit has been festering in a reservoir, poisoning the water supply.

Most Gruesome Symptoms: Well, it eats your flesh. Right off your body.

And it doesn’t spare anybody – one poor dear manages to scrape half her leg off while shaving...

How Long You’d Last: If you don’t drink the water, you’ll be fine.

Otherwise, better start saying your prayers.

  • 1
  • 2
  • 3

Current page: Page 3

Prev Page Page 2
Joshua Winning
Social Links Navigation

Josh Winning has worn a lot of hats over the years. Contributing Editor at Total Film, writer for SFX, and senior film writer at the Radio Times. Josh has also penned a novel about mysteries and monsters, is the co-host of a movie podcast, and has a library of pretty phenomenal stories from visiting some of the biggest TV and film sets in the world. He would also like you to know that he "lives for cat videos..." Don't we all, Josh. Don't we all.  

Read more
Jacob Elordi as the Creature in Frankenstein
Horror Movies The 25 best Netflix horror movies to watch right now
 
 
Michael B. Jordan as 'Smoke' and 'Stack' in Ryan Coogler's new vampire horror Sinners
Amazon Prime Video From Sinners to The Wailing, get scared with our guide to the best Prime Video horror movies
 
 
Thomas Jane as David Drayton screaming at the end of The Mist
Horror Movies People are debating the darkest horror movie endings and, yep, these will keep you up at night
 
 
Cillian Murphy as Tommy in Peaky Blinders: The Immortal Man.
Movies The 25 best movies on Netflix to watch right now
 
 
Resident Evil Requiem On the Radar screenshot of a zombie biting a fire poker with an orange overlay
Resident Evil Resident Evil Requiem is my new favorite Saw movie thanks to one of the most upsetting survival horror levels in history
 
 
Austin Abrams as Bryan in Resident Evil
Horror Movies Upcoming horror movies coming in 2026 and beyond
 
 
Latest in Movies
Close up Noob Saibot's face in Mortal Kombat 2 trailer
Action Movies Mortal Kombat 2 writer reveals the fighter he cut from the script: "I wasn't able to devote enough time to sell him as a character"
 
 
The Mandalorian and Grogu
Star Wars Movies Pedro Pascal says he originally didn't realize Jon Favreau wanted him to play The Mandalorian in the Star Wars show
 
 
Grogu being painfully adorable in The Mandalorian and Grogu
Star Wars Movies Former Lucasfilm president Kathleen Kennedy compares Mandalorian and Grogu director Jon Favreau to George Lucas
 
 
Mando and Baby Yoda in The Mandalorian and Grogu trailer
Star Wars Movies The Mandalorian knows Grogu "will outlive him" so he's "making sure" he "can survive without him"
 
 
andy serkis
Fantasy Movies Andy Serkis says he doesn't see a difference between game and movie acting: "Hollywood is using video game engines"
 
 
Pedro Pascal as Din Djarin unmasked in The Mandalorian and Grogu
Star Wars Movies Pedro Pascal wants to keep playing the Mandalorian for as long as the "many bodies we put into the suit can take it"
 
 
Latest in Features
Lost Odyssey screenshot
RPGs If you loved Clair Obscur: Expedition 33, find a way to play one of the Xbox 360's best-kept secrets
 
 
A Paladin in heavy armor leans on a shining sword
Tabletop Gaming "Our players are going to be pretty psyched": Hasbro CEO talks D&D, video games, and playing to win
 
 
Nathan Drake looks at some ruins as Sam watches, in Uncharted 4, from the PS5's Uncharted: Legacy of Thieves Collection
Action Games 10 years later, Uncharted 4 remains the perfect antidote to overly bleak and serious adventuring
 
 
The official Summer Game Fest logo in shades of purples and blues, with a pink circle surrounding the event's title
Games Summer Game Fest schedule 2026: Dates, times, and where to watch the showcases
 
 
Fox McCloud's rival Falco sitting in the cockpit of an Arwing in a screenshot taken from Star Fox for the Nintendo Switch 2
Nintendo Switch 2 Star Fox 64 remains one of Nintendo's greatest action games, and its Switch 2 remake will prove it to a new generation
 
 
Adeline Rudolph as Kitana in Mortal Kombat 2
Action Movies Mortal Kombat 2 ending explained: who fights, who dies and every fatality
 
 
LATEST ARTICLES
  1. Lost Odyssey screenshot
    1
    If you love Clair Obscur: Expedition 33, find a way to play Lost Odyssey – the cult-classic RPG that remains one of the Xbox 360's best-kept secrets
  2. 2
    10 Games like Persona 5 with brilliant party members, epic stories, and plenty of style
  3. 3
    The Boys fans think season 5's POV episode reveals the order in which major Supes will die
  4. 4
    The Legend of Zelda: Twilight Princess finally gets a fan-made PC port, and I can't wait to see what modders do with the GameCube classic
  5. 5
    10 years later, Uncharted 4 remains the perfect antidote to overly bleak and serious adventuring

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

Add as a preferred source on Google Add as a preferred source on Google
  • Terms and conditions
  • Contact Future's experts
  • Privacy policy
  • Cookies policy
  • Accessibility statement
  • Careers
  • About us
  • Advertise with us
  • Review guidelines
  • Write for us

© Future US, Inc. Full 7th Floor, 130 West 42nd Street, New York, NY 10036.

Please login or signup to comment

Please wait...