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Minor spoilers, as the actor talks to TV Guide magazine
“Castiel [Misha Collins] looks at Sam and Dean and tells them that they're essentially ants in the scheme of things. Now that he’s God, he has no need for them and to stay out of his way... When they track Cas down, they realise that when he took in all those monsters souls from purgatory, there were much older things that got into him as well. There’s a new, basically unknown, enemy in the world. It’s something that the guys have never dealt with.”
And it gets worse! “We're going to start taking things away from Sam and Dean that they've relied on in their hunter life. There's no lore to help them out and no book to tell them what to do. Bobby [Jim Beaver] throws his hands in the air. At one point they might even have to stash the Impala, because it's too recognisable. The lead problem this year, is that all their little tricks that they’ve used to exist, credit card fraud and gambling, those are ways for this evil to track them down. It poses a bit of a challenge for the boys. They throw everything they can at Sam and Dean and they have to wriggle their way out.”
Read more of this interview at TV Guide .
