Skip to main content
Background
Welcome to GamesRADAR+ Community !
Hi ,

Your membership journey starts here.

Keep exploring and earning more as a member.

MY ACCOUNT

Badge picture
Earn your first badge
Read 1 article to unlock your first badge.
Keep earning badges
Explore ways to get more involved as a member.
Latest Games News

Latest Games News

Breaking gaming news and updates

Read Now
Latest Games Reviews

Latest Games Reviews

Expert verdicts on the newest releases

Read Now

See what you’ve unlocked.

Explore your membership benefits.

Explore
Member Exclusives

Stay Ahead with GamesRadar+

Get the biggest gaming news, reviews, and releases straight to your inbox.

Explore

Sign Out
Join The Community
- Join our community
11
Premium Benefits
24/7
Access Available
21K+
Active Members
Commenting
Join the discussion
Exclusive Articles Coming Soon
Member-only articles
Weekly Newsletters
Weekly gaming & entertainment news
Member Badges
Earn badges as you go
Exclusive Competitions
Members-only prize draws
Curated Deals Coming Soon
Tech and gaming deals worth grabbing
GET COMMUNITY ACCESS QUICK
For the quickest way to join, simply enter your email below and get access. We will send a confirmation and sign you up to our newsletter to keep you updated on all your gaming news.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.
FIND OUT ABOUT OUR MAGAZINE
Want to subscribe to the magazine? Click the button below to find out more information.
Find out more
GET Community ACCESS QUICK

Join the GamesRadar community for quick access. Enter your email below and we'll send confirmation, and sign you up to our newsletter.

By submitting your information, you confirm you are aged 16 or over, have read our Privacy Policy and agree to the Terms & Conditions. Geographical rules apply.

GamesRadar+ GamesRadar+
US EditionUS CA EditionCanada UK EditionUK AU EditionAustralia
Sign in
  • View Profile
  • Sign out
  • Games
    • Game Insights
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
    • Genres
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
    • Franchises
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • Insights
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
    • Computing
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
    • Accessories & Tech
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
  • Home
  • Games
    • View Games
      • Games News
      • Games Features
      • Games Reviews
      • Games Guides
      • Big in 2026
      • Big Preview
      • Future Games Show
      • Golden Joystick Awards
      • Action Games
      • RPGs
      • Action RPGs
      • Adventure Games
      • Third Person Shooters
      • FPS Games
    • Platforms
      • View Platforms
      • PS5
      • Xbox Series X
      • PC
      • Nintendo Switch
      • Nintendo Switch 2
      • Tabletop Gaming
      • Grand Theft Auto
      • Pokemon
      • Assassin's Creed
      • Monster Hunter
      • Fortnite
      • Cyberpunk
      • Red Dead
      • The Elder Scrolls
      • The Sims
  • Entertainment
    • View Entertainment
    • TV Shows
      • View TV Shows
      • TV News
      • TV Reviews
      • Anime Shows
      • Sci-Fi Shows
      • Superhero Shows
      • Animated Shows
      • Marvel TV Shows
      • Star Wars TV Shows
      • DC TV Shows
    • Movies
      • View Movies
      • Movie News
      • Movie Reviews
      • Big Screen Spotlight
      • Superhero Movies
      • Action Movies
      • Anime Movies
      • Sci-Fi Movies
      • Horror Movies
      • Marvel Movies
      • DC Movies
    • Streaming
      • View Streaming
      • Apple TV Plus
      • Disney Plus
      • Netflix
      • HBO
      • Amazon Prime Video
      • Hulu
    • Comics
      • View Comics
      • Marvel Comics
      • DC Comics
  • Hardware
    • View Hardware
      • Hardware News
      • Hardware Reviews
      • Hardware Features
      • Buying Guides
      • Desktop PCs
      • Laptops
      • Handhelds
    • Peripherals
      • View Peripherals
      • Headsets & Headphones
      • TVs & Monitors
      • Gaming Mice
      • Gaming Keyboards
      • Gaming Chairs
      • Speakers & Audio
      • Gaming Controllers
      • Tech
      • SSDs & Hard Drives
      • VR
      • Accessories
      • Retro
  • Deals
    • Toys & Collectibles
    • Lego
    • Dungeons and Dragons
    • Merch
  • Video
    • View Video
    • Video
    • GR+ Replay - Submit Your Clips
  • Newsletters
    • Quizzes
    • About Us
    • How to pitch to us
    • How we score
    • Newsarama
    • Retro Gamer
Trending
  • Summer Game Fest 2026
  • Xbox Games Showcase
  • Future Games Show
  • God of War Laufey
  • New Games 2026
  • SGF 2026 schedule
  • Summer Game Fest
  • Best gaming tech
  • Submit your clips. Win prizes
  1. Games
  2. Roguelike Games

Mewgenics review: "The Binding of Isaac collides with Into the Breach in a strategy roguelike that has me battling bomber rats, breeding brutes, and more"

Reviews
By Ali Jones published 6 February 2026
0 Comments Join the conversation

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works.

Mewgenics
(Image credit: © Edmund McMillen)

GamesRadar+ Verdict

A dense, detailed, and hugely varied strategy roguelike, Mewgenics borrows much from its iconic predecessor with an imaginative and rewarding gameplay loop. Occasionally harsh RNG can be a buzzkill, but doesn't prevent this from being a worthy successor to The Binding of Isaac.

Check Amazon
Check Best Buy

Pros

  • +

    Constantly shifting roguelike loop

  • +

    Impeccable soundtrack

  • +

    Widely varied strategy gameplay with loads of replayability

Cons

  • -

    Some random events hinder strategy with no counter-play

Best picks for you
  • The best adult board games in 2026
  • The best 2-player board games to try in 2026
  • Best board games 2026, with hand-picked recommendations from industry experts

Why you can trust GamesRadar+ Our experts review games, movies and tech over countless hours, so you can choose the best for you. Find out more about our reviews policy.

The Ranger quickly became my favorite class in Mewgenics. At face value little more than a standard archer archetype, it quickly becomes indicative of the diversity that underpins this long-awaited roguelike strategy game. A Ranger can be an assassin, dialling up their ranged damage and crit chance to delete enemies from afar. They can be a machine-gunner, firing multiple times in a single turn to thin out enemy numbers. They can be a sentry, taking shots at anything that moves within range to whittle down HP. They can spawn crowd-controlling traps around the arena, or summon multiple familiars to slow down enemy advances.

My fondness for the Ranger, however, has also proven to be my downfall. In this particular run, I've paired them up with a Cleric, whose kit normally revolves around healing, but this time is focused around designating an 'Alpha', and then bestowing powerful buffs on this new leader. On one turn, during a climactic boss fight, I've saved up enough mana to pump my Ranger so full of upgrades that it removes half this boss's HP in a single turn. Unfortunately for me, I've forgotten that this particular boss possesses its killer when it's downed, which means that now I'm facing off against possibly the most powerful character I've ever created. Even with the odds three-to-one against, my Alpha Ranger wipes out their entire team, and I lose the run.

Mewgenics

(Image credit: Edmund McMillen)
Fast Facts

Release date: February 10th, 2026
Platform(s): PC
Developer: In-house
Publisher: Edmund McMillen, Tyler Glaiel

Mewgenics is a roguelike strategy game styled after the narrow combat arenas of turn-based games like Into the Breach. But instead of city-spanning kaiju fights, these battles are somewhat more domestic, initially taking place on the litter-strewn asphalt of a dingy alleyway against rats, mice, bugs, and various stray cats. The fights remain fair because your fighters are also little more than stray cats, which is where Mewgenics starts to veer dramatically away from polite convention and into its creator's unique take on the world.

Latest Videos From
Watch full video here:

Cat Fight

Mewgenics

(Image credit: Edmund Mcmillen)

The long-time brainchild of The Binding of Isaac creator Edmund McMillen, Mewgenics borrows much from its predecessor. Its own roguelike structure may be entirely new, but a toilet-humor aesthetic and multiple Isaac-themed easter eggs are baked in alongside a combat philosophy shaped by replayability; eventually, you'll grow familiar enough with the foes you encounter to plan around their behavior, but the first few meetings will likely be shaped by confusion as you try to work out how they're trying to hurt you.

Your cats will mostly see you safely through each battle, but Mewgenics commits to the roguelike formula by rarely letting you use the same characters twice. Once a unit returns safely home, it's 'retired', and can't be sent out on a new expedition. Similarly, there's a good chance that its gear is worn out, no longer fit to be taken out by a new cat. It's a formula that keeps you rotating through cats, classes, and items regularly, committing to genre conventions by forcing you to build mostly from scratch with each new outing. Initially, it's abrasive, asking you to answer a lot of different questions about your approach before you're in possession of anything like all the facts.

Mewgenics

(Image credit: Edmund McMillen)

But over time, it begins to settle into an effective loop. Your cats head out, and hopefully return safely home with vastly improved stats and fresh gear. Then, those feline heirlooms are passed down to the next generation, and your retired kitties are given a home in which they'll help create the generations that come after that. Each night, there's a chance that cats will breed, passing on their vital statistics and sometimes their abilities to their offspring. A retired cat in a comfortable, well-furnished home will breed more regularly and give birth to kittens in better condition, which will grant you the edge when they're ready to go out on their own adventures.

The powerful Fighter I was trying to breed kept spurning advances night after night.

Breeding is not a transparent venture. I spent multiple days unsuccessfully trying to interbreed my retired Tank class cats in order to create a host of roided-up kittens, but I'm still not sure why those cats weren't interested in each other. On another occasion, it took several days to discover that the powerful Fighter I was trying to breed kept spurning advances night after night because he was more interested in his male housemates than the female ones. And even when cats do breed, there's little guarantee that they do so with the mate you've chosen for them, or that the resulting kitten will have inherited the stats you were aiming for. More than a pedigree breeding program, Mewgenics opts for a rising tide approach, where gradually, the improving condition of your breeding stock will contribute to a slow, steady, upwards cycle that benefits the entire population.

Sign up to the GamesRadar+ Newsletter

Weekly digests, tales from the communities you love, and more

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.

Facing cat-astrophe

Mewgenics

(Image credit: Edmund McMillen)

But it doesn't take much to slip several rungs down the evolutionary ladder. 'Fair' is not an adjective that contributes heavily to McMillen's design philosophy, and Mewgenics is no exception to that. Regularly outnumbered and out-gunned, especially in unfamiliar boss fights, it's a game where you mostly remain the master of your cats' fates, but in which a single roll of the dice can set off a cascading effect where eventual victory is impossible. You can jettison from a run after the battles at the end of each area if you know you won't be able to get through the next one, but if you die before then, your cats, their genes, and all their gear will be lost forever.

Maintaining that constant level of risk is important, but there are times where I've cursed certain aspects of Mewgenics. Random events are unavoidable, and while some are blessings, others are significant banes. One such encounter has the apparently minor effect of making a cat smell bad - a limited inconvenience, you might imagine, but allied cats are forced to use up their movement action getting away from their stinking ally, often costing you an entire opening round and giving your opponents a free shot. An unfortunate roll of the dice is one thing, but the lack of ability to deploy your cats where you want them can mean that an entire run is ended by bad luck, and multiple runs that come after that suffer too.

The cats in Mewgenics encounter a firestorm event

(Image credit: Edmund McMillen, Tyler Glaiel)

The gross-out humor and whacky build interactions that have been a key part of McMillen's work for decades don't distract.

Still, Mewgenics marries its more chaotic elements with the detail required by this kind of strategy roguelike almost perfectly. Wildly varied build paths nestle up against tight strategy gameplay in a way that brings real skill expression alongside deliberate, tactical planning. Innumerable combinations of skills, perks, and items ensure that you're constantly rotating through new ideas and new strategies, even against familiar foes. The lack of guard rails that enables Mewgenics to sometimes feel unfair is also what can make it so delightful when you have a run where you cats break it apart themselves – and being tasked with dealing with a barrage of randomness avoids the build chasing that can whittle down the likes of Hades 2 into becoming predictable.

The gross-out humor and whacky build interactions that have been a key part of McMillen's work for decades don't distract from detailed, finely-crafted combat encounters. And for those looking for the replayability, optional challenge, and cryptic puzzles that shaped The Binding of Isaac and its endgame, Mewgenics is an enormous game - almost 50 hours tells me I've barely scratched the surface of what this game offers, and the direction my progression has gone in differs substantially from what other early players have told me they've uncovered.

For a game 15 years in the making, which has changed almost beyond recognition since its original inception and sits in the shadow of an enduring indie juggernaut, Mewgenics might easily have faded into obscurity. Instead, it's an excellent addition to its creator's already enviable canon, and a notable new pillar in the roguelike pantheon he helped to establish.


Disclaimer

Mewgenics was reviewed on PC, with code provided by the publisher.

Searching for that purr-fect run? Our best roguelike games list has more recommendations for you to scratch that itch.

Mewgenics: Price Comparison
View Similar Amazon US
Amazon
No price information
Check Amazon
Best Buy - View Similar
Best Buy
No price information
Check Best Buy
We check over 250 million products every day for the best prices
powered by
Gamesradar
CATEGORIES
PC Gaming Platforms
Ali Jones
Ali Jones
Social Links Navigation
Managing Editor, News

I'm GamesRadar's Managing Editor for news, shaping the news strategy across the team. I started my journalistic career while getting my degree in English Literature at the University of Warwick, where I also worked as Games Editor on the student newspaper, The Boar. Since then, I've run the news sections at PCGamesN and Kotaku UK, and also regularly contributed to PC Gamer. As you might be able to tell, PC is my platform of choice, so you can regularly find me playing League of Legends or Steam's latest indie hit.

You must confirm your public display name before commenting

Please logout and then login again, you will then be prompted to enter your display name.

Read more
Mewgenics collars
Roguelike Games Mewgenics co-creator says "it's crazy" there are secrets that people still haven't found
 
 
Guillotina in Mewgenics
Roguelike Games Final Fantasy Tactics beat Pokemon when the Mewgenics creators were trying to figure out its combat
 
 
The dino-like Pyrophina beast in Mewgenics roars, shaking the screen
Roguelike Games "Oh hi Switch 2": Mewgenics port looks imminent as Edmund McMillen shows it on Nintendo's hardware
 
 
Hades 2
Roguelike Games The 25 best roguelike games to play right now
 
 
The dino-like Pyrophina beast in Mewgenics roars, shaking the screen
Roguelike Games After Slay the Spire 2 negative review spike, Mewgenics lead says releasing balance patches is scary
 
 
Minos screenshots
Roguelike Games Crafting my own devilish dungeons in roguelike Minos has awakened something villainous inside of me
 
 
Latest in Roguelike Games
33 Immortals
Roguelike Games Spiritfarer devs unveil release date for new Hades-like game they've cooked "for the past 7 years"
 
 
Slay the Spire 2 early access trailer screenshot shows an animated character wearing golden armor, running forward.
Roguelike Games Slay the Spire 2 patch adds a crowd-pleasing buff as fans say one card just became "busted"
 
 
Mel staring head-on with one red eye in Hades 2
Hades Surprisingly big Hades 2 update adds feature we've wanted since the beginning of Steam Early Access
 
 
Hero artwork in Gothic 1 Remake cropped for a header image, showing four characters wielding a range of weaponry including axes, swords, bows, and magic
Roguelike Games What made Gothic so special? Here's why this fan favorite is getting a revival
 
 
Black Jacket
Roguelike Games Black Jacket is a demonic deckbuilder where you can earn a ferry ride out of hell
 
 
Vampire Survivors Legacy of the Bloodmoon DLC
Roguelike Games Vampire Survivors' Legacy of the Blood Moon DLC was initially supposed to be a "little add-on"
 
 
Latest in Reviews
A close-up crop of Butch telling the player to get out of his face in in Gothic 1 Remake
RPGs Gothic 1 Remake review-in-progress: "A beautiful remake of a true original, but too much jank made the cut too"
 
 
Among Us TV show trailer
Animated Shows Among Us season 1 review: "Flashes of creative brilliance, but not as addictive as the game it's based on"
 
 
Asus ROG Zephyrus Duo gaming laptop in dual-screened mode playing Forza Horizon 6 with a guide underneath on a wooden desk
Laptops The Asus ROG Zephyrus Duo has me giddy with excitement, I just wish it made sense
 
 
Skeletor in Masters of the Universe
Sci-Fi Movies Masters of the Universe review: "An enjoyable and self-consciously silly take on outdated source material"
 
 
The Asus ROG Azoth Extreme 20 review  with its RGB lighting on
Gaming Keyboards If you thought previous ROG Azoth keyboards prices were bad, the 20th anniversary is going to give you a heart attack
 
 
A reviewer holding the Asus ROG Harpe II Extreme Edition 20 above a gaming desk with yellow lighting
Gaming Mice The new Asus ROG esports mouse upped my kill-count in my favorite game so I'm questioning my bizarre taste in clickers
 
 
LATEST ARTICLES
  1. Exodus screenshot of Jun zipping along in the air with Big Preview branding
    1
    Exodus narrative director dives into its inspirations from Interstellar to Star Wars to Mass Effect
  2. 2
    Call of Duty DMZ devs have been "paying attention" to other extraction shooters like Arc Raiders
  3. 3
    After over 5 years in early access, Valheim 1.0 launches in September with final biome Deep North
  4. 4
    Persona 4 Revival avoids Persona 3 Reload's biggest mistake and looks like a definitive remake
  5. 5
    Final Fantasy 7 Revelation's story changes based on your choices, but it'll have a "singular ending"

GamesRadar+ is part of Future US Inc, an international media group and leading digital publisher. Visit our corporate site.

Add as a preferred source on Google Add as a preferred source on Google
  • Terms and conditions
  • Contact Future's experts
  • Privacy policy
  • Cookies policy
  • Accessibility statement
  • Careers
  • About us
  • Advertise with us
  • Review guidelines
  • Write for us

© Future US, Inc. Full 7th Floor, 130 West 42nd Street, New York, NY 10036.

Please login or signup to comment

Please wait...