Using the 5-2 def set, spread out your linemen (L1, d-pad up). Control one of the DE's. Audible to slant out your linemen (L1, Right stick up).
Using 4-2-5 def, choose SS blitz and slant your linemen inward (L1, right stick down)
Remember that on any def play, you can audible a LB blitz. Simply hit LB audible (R1), then right stick either left, down, or right (LOLB, MLB, ROLB). If you are in a 3-4, 4-3, 4-4 ect. package, this will work as shown. Otherwise, it will choose the only LB you have (in dime, ect)
The corner blitz works amazingly well in this game, compared to earlier versions!
4-3 LB Blitz works best when you spread out your linemen (L1, d pad up) and scrunch in your LB's (R1, d pad down)
Don't always blitz from the same spot or formation. Come from the left, middle, right, man coverage, zone blitzes, safties, corners, ect., and mix it up! This will keep the AI rattled the best.