In the level where Grissom gets kidnapped try getting a few items including the substance on Leda's book case then go to Brass ask him to re-open the hotel when he says no and gives you the items take the items back to Greg. Then drag the items on to him and he will tell you the items contain the same substance. Then if you have enough try asking Brass again and you MIGHT get in the hotel. BEWARE!!!! it only works if you have the substance and the murder weapon from the first case.
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