Higher Blood Vial maximum.
This is found on the second floor, accessible only via that lantern. Make your way around the perimeter of the building until you spot this large enemy. Across from him is a door that leads to a classroom. Head through, cross the balcony, and enter the small room on the other side. There's chest inside holding this Rune.
Boosts max Stamina.
Now head back to that large enemy. He's guarding a ladder to a locked room on the first floor. Take him out and head down there to come face to face with a spider-man. Not the superhero, but a truly creepy dude. Talk to him to receive this Rune.