When you are back at the hotel again, Glenn will mention that things can’t be that bad to have to kill yourself when thinking of Irene. If you gave her the gun, Glenn will mention it and be upset about it. If you didn’t give her the gun, Glenn will just stare at her room and then leave.
Depending on who you saved in the drug store; either Carley or Doug, they will be in line to talk to while going through the conversation gauntlet. If it was Carley you saved, she will be messing around with a box and will ask you questions about why you saved her. The answers don’t affect the end of the conversation. If you saved Doug, he will be there working on a laptop and have the same questions that Carley had. As with Carley, the outcome of the conversation doesn’t affect anything.