1. Johnny and River (To the Moon)
To The Moon's love story isn't an aside or sub-facet of the main story--it is the main story. When the game begins, you're introduced to Johnny, an elderly man on his deathbed with a dying wish to go to the moon. Well, to at least experience going to the moon, as you're tasked with implanting an artificial memory into his brain so he can rest in peace.
But once you start digging through his life's story, you begin to uncover his troubled relationship with his wife, River, who died a few years earlier. River has a disorder that makes their communication difficult. She creates rooms full of origami bunnies for him and he has no idea why, he writes her a song that she doesn't respond to, she asks him strange questions that he doesn't understand. The deeper you dive into Johnny's memories, the more you learn about their relationship, why they're doing the things they're doing, and why, of all things, Johnny's dying wish is to go to the moon. Oh, and you're going to cry. Oh, yes, there will be tears.