You’ll fight them in: Dead Space 3
Dead Space has a well-established tradition of crafting horrifying, misshapen creatures, a practice the franchise’s developers have expanded on in the next series entry. For example, there’s Nexus, the Godzilla-sized beast that closed out the E3 2012 demo for DS3. The attacks of protagonist Isaac and his co-op partner Carver have little effect on its outside, and the demo seems to end with what appeared to be a hideous death animation of Isaac being eaten by Nexus. Instead, Isaac awakens inside the beast where the battle resumes, only this time it's against Nexus' organs. We feel pretty safe in saying this enemy has the most dangerous intestines of any character on this list.