Charisma is one of Fallout 4 (opens in new tab)'s "softer" stats - it doesn't let you soak or deal more damage, or even help you carry extra loot - so you might be tempted to leave it hobbled in favor of Strength (opens in new tab) or Perception (opens in new tab). And sure, you could definitely do that… if you don't want to be able to charm a hungry yao guai out of eating your face.
The latest Fallout 4 SPECIAL video from Bethesda demonstrates the various and sundry benefits of the Charisma stat - from becoming a better trader to attracting more friends, and even avoiding the perils of chem addiction; Fallout 4's Endurance SPECIAL (opens in new tab) might help you hold your drink better, but Charisma will keep you from fiending for more once the hangover wears off.
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