Dead Space is all about strategic dismemberment, and what is a destructible environment if not strategic dismemberment of… the environment? Taking down necromorphs by collapsing rooms on them would totally make sense (as long as, y'know, the game didn’t take place in a space station), and be a nice workaround to needing to shoot everything’s legs off. It would even mesh well with the series' mechanics - holding an enemy in place with a Stasis, only to shoot a chunk of wall into them, would be awesome.
Not to mention how scary it would be to have enemies take advantage of the destructible objects, too. Hiding behind a doorway only to have a necromorph rip through it would be horrifying, and knowing that literally no hiding spot is safe would make the already tense situations all the more disturbing.