Late eighties Disney flick Honey, I Shrunk The Kids. Wayne Szalinski (Rick Moranis) is the inventor who accidentally shrinks his kids to the size of ants, then has to find them before they're gobbled up by, well, anything bigger than an ant.
The Radically Different Sequel:
Wayne hasn't learnt his lesson, this time accidentally 'blowing up' his toddler so that he's 14 feet tall - and a tantrum-throwing menace to society.
Well, it goes the complete opposite to the first film. Clever, eh?
If the first film was an ode to the creature features of the fifties, this first sequel is more akin to
Attack Of The 50ft Woman.