Gaming's maddest mad doctors

The mad scientist has been an archetypal breed of character for years. Centuries, in fact. From Doctor Moreau to Doctor Giggles, the worlds of literature, television and film have been filled with scientists and surgeons who sport a Ph.D in crazy. Naturally, videogames are no different.

In memory of some of gaming's most mental scientists and demented quacks, we present this humble list. They're all geniuses, but they're all completely over the rainbow. Read on as we take you on a tour through gaming's maddest mad doctors.

Dr. Neo Cortex

From: Crash Bandicoot
Speciality: Artificially stimulated evolution, putting pants on animals

Dr. Neo Periwinkle Cortex is the ultimate cliche. Bullied as a child, Cortex's ambition of world domination is driven by the ridicule he's suffered over the years. Boasting a massive cranium matched only by his ego, and resplendent in the obligatory white lab coat, elbow-length rubber gloves, and evil beard of villainy, Cortex is everything a mad doctor should be. He's also quite, quite mad, as evidenced by the fact that he has an army of rapidly evolved animals that he thinks will help him rule Earth. The big "N" plastered on his forehead probably isn't great evidence of emotional stability, either.

Dr. Nefarious

From: Ratchet & Clank: Up Your Arsenal
Speciality: Time travel, destruction of anything with a pulse

Nefarious is the personification of self-loathing. His hatred of all living things pushed him over the brink of madness, despite the fact that he himself was once a biological life form. Fortunately, that's no longer a problem because he is now a robot and therefore free to pursue a genocidal war against the "squishiness and foul stench" of organic beings. In short, he's a complete lunatic who wants to disintegrate anything that isn't made of metal and rule a galaxy populated entirely by machines. Pretty cuckoo, then.

Adrian Baker

From: Heavy Rain
Speciality: Extreme surgery, roofies

Adrian Baker is one of many "rent-a-villains" found in Heavy Rain, who seem to exist solely to wave their hands around and shout, "I AM QUITE SUSPICIOUS MAYBE I AM THE ORIGAMI KILLER ACTUALLY!" Also known as The Doc, Baker is one of the craziest suspects found in Quantic Dream's quasi-film, as evidenced by his love of drugging young women and performing surgery on their conscious, unaneasthetized bodies. He himself is happy to admit that he went a little peculiar after he lost the ability to perform real surgery, but that's okay. A circular saw in the basement and a city full of soft female flesh is more than enough to make up for it.

Dr. Killjoy

From: The Suffering
Speciality: Curing the criminally insane, being criminally insane

Dr. Killjoy is the classic lunatic running the asylum. Although he genuinely desires to fix the minds of the psychopaths on Carnate Island, his methods are said to be depraved (not to mention often fatal) and his current existence as a living memory who seeks to "cure" protagonist Torque hasn't seemed to do much for the man's sanity. Appearing throughout The Suffering as a sixteen millimeter film projection, Killjoy attempts to help the criminally insane in the only way he knows – by sending blinded freaks with swords for arms after them.

Dr Baldhead/Faust

From: Guilty Gear (series)
Specialty: Lacerating opponents with a six-foot scalpel while wearing a bag over his head

Okay, stay with us on this one: Faust – who is supposedly 360cm (11 feet, 9 inches) tall – was originally named Dr Baldhead, and he was a genius of a physician. But he wasn’t infallible, and when a little girl died on his operating table, he dealt with the pain just as any medical professional would: He went batshit insane and became a serial killer. However, when the ghost of the little girl who died appeared to him and said it wasn’t his fault, he became UN-insane again (note we didn’t say “sane”), changed his name to Faust, and rededicated himself to preserving life and fostering peace. However, the fact that his peacekeeping methods involve him wearing a bag over his head and slashing away at other people with a gigantic scalpel leads us to question just how sane he’s become. We’re going with, “not quite sane enough.”

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  • Bravo315 - April 5, 2011 6:52 p.m.

    GR should make a part 2 of this lost and add Dr Salvador, Dr Mario, Dr Richtofen, Dr Breen, and The Dr from Assassin's Creed that experiments on his patients. Great idea and list though!
  • alfonso.hdez - April 1, 2011 9:04 a.m.

    OK Gamesradar, there are 3 comments regarding MDK & MDK2, how 'bout some love for that game? It's like my own personal Okami here.
  • alfonso.hdez - April 1, 2011 9:02 a.m.

    @JD_Method I thought I was the only one who played MDK and MDK2! absolutely loved those games, they were just brilliant
  • killtaculor - April 1, 2011 5:48 a.m.

    This is a great article. I love Dr. Nefarious and Neo Cortex. I was just on Ventrillo earlier with some friends and we were discussing how bad ass the original Crash Bandicoot games were.
  • AntmanG93 - April 1, 2011 1:56 a.m.

    how about Dr. Loboto from psychonaughts?
  • EwoksTasteLikeChicken - April 1, 2011 12:29 a.m.

    Where's the mad scientist from Stubbs the Zombie in Rebel Without a Pulse? I know not many people have heard of it, but the guy created all the zombies, experiments with normal humans, and flies around with a jetpack.
  • InfamousGamer - March 31, 2011 9:59 p.m.

    What about Edward Richtoften? I mean, for God's sake, he created ZOMBIES! How is he NOT on the list?
  • ChickenFillet5140 - March 31, 2011 4 p.m.

    Alex the Great seemed like a pretty cool guy so I denied myself the pleasure of frying his heavily mutated ass. Another Great article Jim.
  • Cleanser247 - March 31, 2011 3:38 p.m.

    GREAT article Jim! I agree with your choices : ) I'm glad you included Bioshock as well!
  • philipshaw - March 31, 2011 3:20 p.m.

    Articles like this is why I come to GR every day,great stuff
  • mothbanquet - March 31, 2011 2:34 p.m.

    And I was about to yell at you for neglecting Steinman; before I found you saved the best for last! An awesomely creepy character, really sent a shiver down my spine.
  • Imthedoctor - March 31, 2011 5:24 a.m.

  • NanoElite666 - March 31, 2011 5:07 a.m.

    DR. RICHTOFEN WANTS TO BATH NAKED IN YOUR BLOOD!!!! Also, do you have the time? Ha ha ha...
  • FreedomPhantom - March 31, 2011 4:07 a.m.

    I think the Bioshock (1) doctor was the craziest
  • JD_Method - March 31, 2011 3:38 a.m.

    @SacredZergling Haha. No problem. It's a great, fun game. I must dig it out and play it again sometime.
  • FlyinHawaiian13 - March 31, 2011 3:31 a.m.

    Richtofen: "Usually the voices in my head sound so angry." Probably a solid choice for this list.
  • bigmac515 - March 31, 2011 3:14 a.m.

    how about Richtofen from nazi zombies... he made hell hounds and the gas monkey things... WHO THE HELL ACTUALLY THOUGHT THAT GAS MONKEYS WERE A GOOD IDEA!!!
  • crazyj10 - March 31, 2011 2:32 a.m.

    Actually, the Medic isn't a doctor. He doesn't have a degree. But he is still a psycho.
  • Ashkael - March 31, 2011 1:56 a.m.

    Nothing on Dr. Breen from Half-Life 2? He sold out the whole planet to the Combine and then proceeded to forcefully sterilize all of humanity.
  • Yeager1122 - March 31, 2011 12:22 a.m.

    The medic awsome love me some team fortress gotta play zombie island of dr.ned to bad i sold borderlands maybe ill buy the game of the year edition.