Maybe you inhaled too much irradiated dust, but Amata is starting to get on your nerves. You can't kill her in the beginning, but a little later in the game you have a chance to return to Vault 101. Still pissed about her sassy remarks at your tenth birthday party? Let her and her dismembered limbs know how you feel.
Alternatively, you can evacuate the vault. Amata won't make it very far.
Your ability to pick pockets has more than just utilitarian applications - it can be fun! Stick an explosive into the pants of anyone who you're tired of looking at, stand back, and watch fun happen.
Note: Before you proceed, know that the following video contains parts of the game's ending, so if you haven't gotten there yet, consider whether or not you want it spoiled (though this is only one of many possible endings, they are all roughly the same).
At a certain point in the game, you receive a not-so-nice virus. Place it in the filtration system at the end, and it will spread into the water supply, killing every poor little mutant out there. It's not the most honorable ending.