Final Fantasy XII
This is the big one. The next single-player Final Fantasy is looking to be so epic that there might even be more to do in it than in massively multiplayer FFXI.
Expect a shake-up of the Final Fantasy formula: for instance, you can see, and fight, enemies while exploring the world map. With a more serious storyline and art style (even chocobos look menacing) it'll be heavy going, but there's nothing else like it.
A U.S. release date hasn't been set yet, but expect it late this year.