37. Trauma Team
We've used the Wii Remote as many things throughout the life of the console: swords, guns, and steering wheels, to name a few. Trauma Team turned the controller into an instrument of life, letting us control a scalpel, bonesaw, and whatever else we needed to save the person on the operating table.
Trauma Team let us tackle many different areas of the medical profession. Surgery, first response, and endoscopy were all equal parts tense, exhilarating, and a hell of a lot of fun. We sincerely doubt we'd be able to handle the pressures of real-life medical procedures (some of us can't even handle a flu shot), but Trauma Team made us feel like bona fide doctors without the years of college.