11. Wii Sports (2006)
Scoff if you want, but before you start ranting about waggle controls, consider that Wii Sports has sold over 80 million copies. Seriously, think about that--80 million copies. Sure, you could argue that the numbers were bolstered due to the game being a pack-in with the Wii in North America, but that's still an insane figure. Hell, we'd actually argue that most of the parents and grandparents that bought a Wii did so specifically because of Wii Sports--the console was essentially bundled with the game at that point, not the other way around.
Wii Sports launched gaming into the mainstream like no game had before. It was referenced in movies, played on talk shows, and flashed in commercials. It lowered the barrier of entry for games so that anyone could play them, while also showing off that console gaming could be accessible for everyone. And, at the same time, it was a proving point for motion gaming, which would continue to grow for the next eight years, leading to Sony creating Move, and Microsoft developing Kinect.