42. Onegin (1999)
The Story: Eugene Onegin (Ralph Fiennes) catches the eye of young socialite Tatyana (Liv Tyler), who professes her love for him.
Uninterested, though, Onegin merely ignores her advances.
Saddest Part: Years later, Onegin meets Tatyana again, and makes it his mission to win her hand.
However, Tatyana is now married, and has no intention of cheating on her husband.