When you get to him it is important to use the surroundings. He is almost invincible: only cross is making some damage. But he have a weakness. You should do the following: Put your self on a high position (above the ground), the highest place possible, then when he charges on you jump toward him, and try to jump into him. You won't be able to do this in your first try so keep trying. Once inside of him just sprinkle him with some holy water and he will be instantly killed ;).
The game is completely randomized to the point that you should save constantly esp after you locate a family member to save. If you don't and you die, when you go back to that room to save them they will most likely not be there but somewhere else. A good idea if this happens is to reload the last start point and keep going back to that room .Reloading each time. On average every third time or so they will reappear so don't stress to much.
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