Captain Commando

First Appearance: Captain Commando (Arcade) 

One of Capcom's first mascots, Commando showed up on the manuals and boxes of early Capcom games, with his name made up of his company's - Cap. Commando. Eventually he got his own brawler, taking place in the now not so distant future of 2026. With the help of his Commandoes he cleans up Metro City of the future. With his fancy armor and special attacks it gives him, Commando made the world of the tomorrow a safer place, but in the present he's no longer Capcom's mascot, but does appear from time to time.

Charlie

First Appearance: Street Fighter Alpha: Warrior's Dream (Arcade) 

The most famous corpse in Street fighter, Charlie was first introduced as Guile's reason for vengeance against Shadaloo, as Chaz was killed by M. Bison. Charlie's basically the proto-Guile, sharing many of his moves, including the famous Sonic Boom. But death always haunts him, as every ending of his the Alpha games involves him dying.

Chun-Li

First Appearance: Street Fighter II (Arcade)

Probably the most well known and popular woman in fighting games, Chun-Li and her insanely huge legs have been fighting Shadaloo through Interpol for years. Her hatred for Bison is from him killing her dad, which was apparently on a Tuesday. After Bison's defeat, her purpose receded, but she's always brought back into the world of street fighting, putting her lightning kicks to good use. 

Colossus

First Appearance: Giant-Size X-Men #1 

Hailing from Mother Russia, Piotr is one of the most famous X-men around. With the ability to make his skin become bullet-proof metal and at the same time becoming incredibly strong, he's long been the muscle for the mutant super team. At one point he died saving the world's mutants from a killer virus, but has since returned to the living like any popular comic character. Fun fact: when in his organic metal form Colossus needs no rest, food, or even oxygen.

Cyclops

 

First Appearance: The X-Men #1 

Seen as the first X-Man, Cyclops has often led the team into their greatest battles, while simultaneously being teacher's pet to Prof. Xavier. His mutant abilities manifest in powerful optics blasts that are purely concussive, not heat based. They are incredibly powerful, being known to easily turn rock into powder. On top of that he's a born leader and very well trained in martial arts. He's uniquely adept at fighting blind, as he must keep his eyes closed if he can't control his ocular beams.

Dan

First Appearance: Street Fighter Alpha (Arcade) 

Dan went from total joke to a fool you want to root for. Created as a parody of a rival company's character, the laughably weak Dan is disproportionately confident of his style. Blaming Sagat for killing his father, he's been hoping to one day best Sagat, if only he could win a match first. Also, he was Sakura's sensei for a time, before she realized he had nothing to teach her. For the ultimate source of Dan knowledge, check our lengthy retrospective.   

Dhalsim

First Appearance: Street Fighter II (Arcade) 

Dhalsim and his strange mysticism have become a part a fighting history. A peaceful soul only who only got into fighting to earn money for his village, when not in combat he is living at home with his wife, son and elephant. As far as other accomplishments, the stretchy fire breather helped free Cammy from her brainwashing. 

Doctor Doom

First Appearance: Fantastic Four #5 

Born a Gypsy, Doom's brilliant intellect brought him to the greatest schools in America, until a freak accident (which he blames on Reed "Mr. Fantastic" Richards) scarred his face. He left academia, made a metal suit, took over a small European country and dreamed only of revenge on the infernal Richards. On top of his powerful suit, he's also the second best sorcerer on Earth, and can invent nearly anything. Though normally the foe of the Fantastic Four, sometimes his plans for power bring him in conflict with all of Earth's heroes.