Who is she? Catalina. When she's not robbing banks, distributing drugs or running a vast Colombian crime cartel, Catalina enjoys curling up with a good book.
Where's she from? Grand Theft Auto III (2001 - PS2)
What the hell is wrong with her? By seducing the mute hero of GTA III into a hopeless life of law-breaking - and then betraying him for her own personal gain - Catalina guaranteed that she would be the only woman on this list to actually fit the proper, smarty-pants definition of a femme fatale:
femme fa·tale - noun: an alluring woman whose charms ensnare her lovers in bonds of irresistible desire, often leading them into compromising, dangerous, and deadly situations. [French: femme, woman + fatale, deadly.]
Sadly, her melted and misshapen face, her giant ham hands, the broken bag of polygons that's supposed to pass for her body and that god awful voice also guaranteed that she'd fit our definition of a seriously unsexy femme fatale. Oh well. See ya in San Andreas, kid.