Mary Jane... Spider-Man 1-3
Honestly, this entry has nothing to do with the comic book character and everything to do with the actress who portrays her. Let's compare, shall we?
Mary Jane: redhead. Kirsten Dunst: blonde. Mary Jane: green eyes. Kirsten Dunst: blue eyes. Mary Jane: flawless smile. Kirsten Dunst: toothless smile. Mary Jane: spunky, vivacious. Kirsten Dunst: sleepy, possibly stoned.
The two are simply a ridiculous mismatch. We disliked the casting in the films and we dislike it even more in the games, where Kirsten provides MJ with either a bizarre 3D likeness or a bored voice performance. Sorry, but as long as one damsel comes packaged with the other, we don't think she's worth the wasted web.