Your civilization has to survive and have the highest score by the year 2100. By that time you win a domination victory automatically. But you only have to destroy one civilization. (That does not include the Barbarians, but you can defeat them too.)
To kick of a game choose the Spanish as they start off with Navigation. After creating your city create 2 warriors and a Galleon load 1 into the galleon and keep the other there. Then sail off in search of friendly villages and artifacts more important the Atlantis artifact which can be found any where on the map on sea squares. If you find Atlantis you will get 3 free techs, the one that you were researching, and 2 other free techs. Note: you can not choose the techs it chooses for you. But this is a great way to gain a lead in Technology
640K Ought to be Enough (30) - Win a Technology Victory on at least King difficulty.
80% of Success is Showing Up (5) - Accumulate culture to unlock a famous person.
A Great Wind is Blowing (15) - Win as a Russian civilization.
A Knight Without Fear or Blame (15) - Win as an Arab civilization.
A Penny Saved is a Penny Earned (20) - Win an Economic Victory.
A Revelation of Man (20) - Win a Cultural Victory.
A Short Life of Glory (15) - Win as a Greek civilization.
Absolute Power is Kind of Neat (25) - Win without changing governments on King difficulty or higher.
All Others Must Fail (15) - Win as a Mongolian civilization.
An Indomitable Will (15) - Win as an Indian civilization.
Before all Else, Be Armed (5) - Earn a special unit ability in combat.
Blood and Iron (15) - Win as a German civilization.
Buy the Ticket, Take the Ride (3) - Make contact with another civilization.
Citizen of the World (45) - Win a Cultural victory on Deity difficulty.
Culture is Worth a Little Risk (9) - Build a Wonder of the World.
Curse of the Drinking Class (25) - Develop a city to produce 200 resources per turn.
Destroyer of Worlds (30) - Win all types of victories (Domination, Technology, Cultural, and Economic).
Difficulties Mastered (30) - Win a victory with each civilization.
Embiggens the Smallest Man (30) - Win a Cultural Victory on at least King difficulty.
Fair and Softly Goes Far (15) - Win as a Spanish civilization.
Flower and Song (15) - Win as an Aztec civilization.
Good Afternoon, Doctor Jones. (9) - Discover an ancient artifact.
Have Fun Storming the Castle (20) - Win a Domination Victory.
Here's Looking at You, Kid (45) - Unlock all famous persons.
Home is Where One Starts From (3) - Construct a special building.
I Will Not Be Triumphed Over (15) - Win as an Egyptian civilization.
Ideas Control the World (20) - Win a Technology Victory.
Imagination Rules the World (15) - Win as a French civilization.
Indistinguishable From Magic (45) - Win a Technology victory on Deity difficulty.
Let a Hundred Flowers Bloom (15) - Win as a Chinese civilization.
Napalm in the Morning (3) - Defeat an enemy unit.
Once More Unto the Breach (5) - Combine three identical units into an army.
One Mistress and No Master (15) - Win as an English civilization.
Organized Knowledge (25) - Develop a city to produce 200 science per turn.
Playing the Game (45) - Win an Economic victory on Deity difficulty.
Power Never Takes a Back Step (25) - Win with only one city on at least King difficulty.
Scientia Potentia Est (3) - Complete development of any technology.
Such Joy Ambition Finds (45) - Win a Domination victory on Deity difficulty.
That We May Live in Peace (25) - Win the game by year 1000 AD on King difficulty or higher.
The Fruit of Labor (5) - Build a second city in a game.
The Guy Who Signs the Checks (30) - Win an Economic Victory on at least King difficulty.
The Root of All Evil (25) - Develop a city to produce 200 gold per turn.
The Universal Brotherhood of Man (25) - Develop a city to produce 100 culture per turn.
The Will to Win is Everything (25) - Win 20 battles with one unit.
This World is a Harsh Place (15) - Win as an African civilization.
Veni Vidi Vici (15) - Win as a Roman civilization.
Vi Victa Vis (30) - Win a Domination Victory on at least King difficulty.
Victory Over Lesser Men (15) - Win as a Japanese civilization.
We the People (15) - Win as an American civilization.
What is the City But the People? (25) - Grow a city to size 20.
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