Resident Evil 5 Strategy guide and Boss guide

Acts 1 and 2Acts 3 and 4 | Act 5 | Act 6 

Chris finally discovers the source of the Umbrella’s progenitor virus, and a top secret underground lab right beside it. It looks like Tricell have resumed Umbrella’s work, and the lab isn’t as empty as first assumed.


Resident Evil 2’s lickers make a welcome return, albeit in a new, genetically superior, beta modification. And they’re pretty tough too.

After a couple of teases two lickers will leap out of the glass holding tank that lies just beyond the caged test animals. You’ll find that sometimes they fake their own death (clever chaps, aren’t they?). Aim at a writhing licker and if there’s a red dot it’s still alive. If the laser doesn’t register the licker then it’s dead.

However, for all this the lickers have poor eyesight, meaning you can creep past them without fear of an attack if you tread very carefully. Unfortunately they reproduce very quickly, though, so if they hear you you’ll be surrounded by the critters in seconds. They always attack in large numbers so bigger weapons are definitely recommended for taking them out.


You’ve had it lucky up until now. The majini have now ditched their bottles and knives in favour of some full-blown army gear.

You’ll meet these three grunts (above) early on. Run up to the striped crates at the bottom and take cover before trading fire or you’ll not get far.

Chapter 5.2 is a good time to invest in the bulletproof vest. From now until the end of the game it’s all about using cover to overcome the soldiers.

After the first two rooms there are lots of explosive barrels to use. Strike them and you’ll kill half a dozen majini with one bullet.

Flash grenades are a pain. Not only do they white-out your screen for two seconds, they remove you from cover. Make sure you don’t stray into gunfire when blinded.


The reapers are the toughest ‘standard’ enemies in the game. Thankfully there’s one massive chink in their armour.

The first reaper appears once you’ve restored power to the broken conveyor belt with the test subjects. Run past it, power up the belt and hop on.

The reaper will chase you. Stand on the strip between the second and third belts and let it get near. Then, use the shotgun to knock it over. The reaper will now slide straight into the furnace!

The test subjects make things difficult for you. If one grabs you, waggle the left stick to shake it off and pick up their treasure afterwards.

Reapers possess a one-hit kill, but let the others get close and fire one magnum shot into their yellow belly when they’re uncovered. The one-hit KO goes both ways…

This act’s most powerful weapons:

The powerful AK-74 is in the control room off the corridor just past the first two lickers. The room’s on the right, just before you exit this level

Sig 556

Talk about out in the open… You’ll spy the Sig 556 on the table by the conveyor belts with all the ‘dead’ test subjects. Grab it now while there’s nothing about

H&K PS-1

The case with the H&K PS-1 is in the small generator room you visit to power up the horizontal platform. You’ll probably be in a hurry – it’s just after the reapers attack

L.Hawk (Magnum)

Head up to the last room on this arena’s top level and push the coffin open with Sheva. Inside are two expensive gems and one very useful magnum. Don’t waste the bullets on Wesker.

It’s just relentless in here. Once the vault’s elevator is activated the facility’s arachnoid guardian springs into action:

The U-8 appears without warning, and it’ll greet you with an instant-death QTE. If you survive, quickly pick up the hand grenade lying on the platform

Its two main legs have exposed fleshy muscles. Pick a leg and blast it with a powerful weapon (the upgraded shotgun’s perfect for this)

Weaken the leg sufficiently and the U-8 will collapse. Now just run to its mouth and toss one of your grenades inside its sticky gob

Two cycles of this and you’ll expose its cranium. Now focus all your fire on the brain and you’ll send it off to spider heaven. Hurrah

The only attack to be wary of comes from these flying critters. They trap you in sticky goo, so blast them whenever they appear before attacking the U-8


The Uroboros is back and, sadly, there’s no furnace about to kill him with this time!

Locate the three gas canisters and knock them over. Every time the Uroboros gobbles one up, shoot the canister to set Mr Mkono alight

When the flamethrower’s full, pick it up, get in close and go crazy. When it’s on fire it’ll grow bulbous targets, so make sure Sheva’s equipped to shoot ’em

Alternatively, hand the flamethrower to her and shoot them yourself. Keep one eye on the flamethrower ammo and be prepared to refuel it once it’s depleted

A scrap with STARS Alpha team leader sounds like fun, but we’d advise you to just run, run, run:

You’ve got to survive this fight for seven minutes, that’s all. Head to the blue door to your right and Wesker will smash you through. This now gives you the run of the paddock

Use your map to track Wesker and stay ahead by running laps around the one-way circuit. Jill doesn’t show on the map, so grab her from behind and let Sheva knock her out if you spot her alone

There’s plenty of cover in the upper levels but there’s no point in using it. Wesker will soak up a couple of bullets and simply dodge the rest. Survival’s your only goal. After seven minutes you’ve won

You need to stay close to Jill to win this one. Give her space and she’ll just shoot you with her Uzis:

Run up behind Jill and hit X to hold her steady. Then hammer A to keep her there until Sheva shoots Jill’s mind control chip

Jill usually fights back afterwards, so get ready to dodge as soon as she breaks free from your grasp

Keep at it and Sheva will knock Jill down. All that remains is to rip the device from Jill’s chest by pressing a as fast as possible.

1. The wooden crate, is traded in chapter five for a canvas version. It still houses ammo and health though, so equip that knife and get slashing.

2. When you’re on the second conveyor belt be sure to shoot every gas canister ahead, even if there are no majini about. Be wary of grenade blasts.

Next page: Act 6


  • TotalKillLOL - June 22, 2009 1:44 a.m.

    Still an awsome game and great graphics and display. although I hate how long the last level takes
  • DantezGirl - June 11, 2009 10:37 a.m.

    Very Cool Game Thaanks For The Help
  • Garry - April 13, 2009 8:33 a.m.

    I have dis game It sucks my head. The town wars i think second wars in starting of game it is sooooooooooo difficult. There r infinite Zombies.
  • Redfield32 - April 12, 2009 9:14 p.m.

    Another RE game after this would kinda be umm weird. I mean you killed the Wesker clone umbrella is f*cked over now what? Be like Final Fantasy and do what happened before RE and play as Umbrella Corp instead of BSAA? Im not saying it would be bad I'm just saying what else is there to add really? Im only at the part with the native guys.
  • GYJX - March 29, 2009 7:04 a.m.

    Ok guys Im new so what up To the point Im not good at english but I going to try.... I know a really easy way to kill Wesker at the volcano, it took me less than 5 minutes on veterans mode which is the third level cause once you beat the game on that level it comes a harder level. Anyway, here I go When you hit the rock so Sheva can jump to get to high groud Wesker follows you, he rise his arm, we all know that, we also know that we have to hit his back so he can show the orange thing on his chest. I hope that you guy can understand me..... When he shows that orange thing on his chest his going to walk towards you, shoot the orange thing till he looks hurt I mean he is not going to move get close to him and the circle button will show up on the screen this is on PS3 Chris will jump to weskers back and he is going to ask Sheva to shoot the orange thing Sheva is going to say that she cant shoot that thing unless she shoots through Chris too so instead of that I dont know what options you have as Sheva but she uses her knif and start to slash wesker if you do that correctly Chris is going to jump to the ground and slash his back too and there his dead Sorry for my english I hope that you guy understand me please if you have any questions or you kill wesker the way I did please I beg Send me a mail to this
  • tylerlldsarg56 - March 27, 2009 12:51 a.m.

    its ok in scarinest i guess ive bout beat it
  • MrDanHalen - March 26, 2009 6:26 p.m.

    OK 2 things to add. 1) you can do more damage to Jill by having Chris/Sheva hold her while the other shoots the device on her chest... takes 4 tries instead of 8 2) Wesker is a clone (the whole wesker family are just clones).... just because he looks dead, does not mean he's gone forever.
  • Nefarious1 - March 24, 2009 1:10 a.m.

    @phoenix_wing: your name alone suggests "the return". I seriously hope that the RE series continues on into the distant future. Just want them to bring actual ZOMBIES back to the series... Maybe a 2 player CO-OP S.T.A.R.S mansion/underground facility revisited.
  • Nefarious1 - March 24, 2009 12:53 a.m.

    young gamers...remember, a very high percentage of RE is preparation, timing and alot of hand cannon recoil. 1st thing I would suggest to all who are having problems with Bosses and such is to MAX out your Magnums. Very few baddies can stand a blast from one of them let alone two (head) shots. Hit those missions hard, sit back, relax and push the limits of the'd be suprised at what u can get away with when u get in close enough to most baddies. Beating the game in -5 hours is very reasonable once you've learned your enemies "comfort zones".
  • Samael - March 22, 2009 5:59 p.m.

    "(ignore Chainsaw No 2)" Ugh, easier said than done. And what about the third chainsaw guy that comes when you're covering Josh? God I hate them!
  • phoenix_wings - March 17, 2009 7:19 a.m.

    I surprisingly didn't have too much difficulty with the bosses. Unfortunately, I didn't know that you could just run around and not blow through all of your ammo on Wesker...I should have read the guide first. Lesson learned. RIP Wesker...I've got to say that the best way to go would have to be in a volcano...I really hope he didn't make a clone of himself or something. Don't get me wrong, I love the RE series, it's just that I think it's time to close the book on this iconic series. And of course the reCaptcha is Continued Dalai
  • HorrorGod - March 17, 2009 6:16 a.m.

    I just beat RE5 today. As a fan of the series (Resident Evil 1 was the reason I bought a Playstation in '96) I have to say I think this was the best one yet. It was nice that it came back to the original characters that started it all. (After Leon got his own game with 4) Anyway, I just wanted to add to the tips and let everyone know you can defeat Wesker in the end with just a QTE. After you beat up the rock and have Sheva join you, you will have the last battle with Wesker in the middle of the circle area. DON'T RUN AWAY. I was screwed on ammo on this point and I could NOT beat him. I would shoot and shoot until his weak spot would show, and I'd shoot more, until my guns went "click". Finally I just ran up to him to see if I could do a QTE (when his weak spot was visible on his chest) and it allowed me to have a QTE. I held him down and Sheva began slashing away with her knife. BOOM, he was down and out. MUCH easier than what other people have been saying on forums (about stocking up on ammo and blasting it.) Hope this helps anyone who may be stuck at this part.
  • darknessexzero - March 17, 2009 3:21 a.m.

    I think wesker should have died sooner he appears to much
  • gtrko - March 16, 2009 10:21 p.m.

    RIP: Albert Wesker Resident Evil games wouldn't be the same without him *sniffle*
  • Diamondis - March 16, 2009 1:54 p.m.

    As soon as I saw Wesker in the trailers for this game I was upset. Not because I don't like Wesker, because I do... But because I knew he would be the last boss and die =( R.I.P Wekser.
  • Mystery514 - March 14, 2009 5:10 p.m.

    Thanks guys, I really needed this!
  • thekk2007 - March 14, 2009 9:07 a.m.

    I had to do the Final Boss with no ammo on normal!!!!! I used a stun rod keep hitting him untill his heart come out do that for about 8 times and I did it yay
  • NelosAngelos - March 14, 2009 2:38 a.m.

    bout time you beat that bastard down. I only read the boss fights so there wasn't anything to amazing spoiled for me. Can't wait for it.
  • GigaBowser12 - March 13, 2009 9 p.m.

    *Sniffle* RIP Wesker....
  • oryandymackie - March 13, 2009 4:59 p.m.

    If only there were Regenerators in this, that would make this game complete. Disturbing in the jail in RE4 when it lurches slowly towards you down the long corridor.

Showing 1-20 of 30 comments

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