My special setup at the beginning is this:

S 6
P 6
E 6
C 1
I 9
A 6
L 6

First thing i did was running to Rivet city, claiming my Intelligence Bobblehead, so i got 10 Intelligence.
Now you 'll recieve (up to level 20) a total number of 427 skill points.
(19 + 20 + 20 + 16 x 23 = 427, 19 because your intel is 9 and there is no way you can get the Bobblehead before going to level 2)

Now you got about 33 points for eacht stat. This will allow you to take every skill to level 50. Now you also have different tag skills and perks to boost it, so you can easily say, you could get 65 of each skill. besides, you also got the "Skill Bobbleheads", improving your stats to 75.
Now you also have a huge amount of books (25 for every skill, except barter which has 24), so that would make your skill 100, without using Comprehension.

I would would personally always pick Comprehension as a perk.
It still gives you a nice boost at reading books. Finding 13 books is always better then 25.

**Note**
If you really want to max out your stats, just make sure you take the Educated perk at level 4 and the Comprehension perk at level 5.

**EDIT**

last lines should be:
I am not exactly sure when this signal starts to transmit. I first heard is during the mission where i had to retrieve the G.E.C.K.

I see there is some confusement anout the strength and Medicine Bobbleheads.


The strength Bobblehead can you find in Lucas Sims house
To get in:

- Pick the lock
- Pickpocket the key from Lucas Simms
- Kill Lucas Simms for the key
- Accept the quest to blow up Megaton and rat out the guy in the Saloon to Lucas Simms. Then follow Lucas Simms to the Saloon and watch the guy who wants you to blow up Megaton kill Lucas Simms.
- Disarm the bomb. Now the door is unlocked from time to time.

If you decide to blow up Megaton, MAKE SURE YOU TAKE THE BOBBLEHEAD BEFORE YOU DO IT! Once Megaton is gone, so is your bobblehead,

Now about the Medicine Bobblehead.
You can get it:

- When you turn 16, Your father will look if you are able to take tho goat test, on your fathers desk stands the Bobblehead.
- During the quest ESCAPE!
- In the quest where you return to Vault 101.
You can get this quest, by walking around the area around Vault 101. Eventually, you ll revieve a signal from Amata, asking for your help. I am not exactly sure when this signal starts to trsnamit. During the mission where i had to retrieve the G.E.C.K.