I dont know about the rest of you but quick time events get on my nerves this gen, RE5 is one of the top abusers of this. I always feel like that stuff pulls me right out of the game and back to button mashing, force unleashed is another one. Boss fights end in some quicktime event that has me not watching how the boss dies but watching what buttons I need to be pressing. I didn't buy into the whole GH/ rock band fad for a reason. STOP DOING THIS DEVS
I personally think number 3 is the most irritating. I always get a little annoyed when supposed "moral" decisions are based on shallow interpretations of morality. Like the "good" decision being just plain silly or naive.
Or simply forcing your character to have to help or not help a certain character. Why do I have to fight the super bad guy? I wanna ask him for an application :)