So many games I would love to see:
Little Big Adventure 3 - simply unique, haven't seen an adventure game with the same witty world as the LBA's franchise. Freelancer 2 - loved the first, a sequel with more sandbox elements would be epic. Dungeon Keeper 3 - DK series had an awesome approach to the RTS genre, killing the good guys was never so fun.
I need to find out what happens to Uncle Antan Azzameen in the next Star Wars X-Wing Alliance combat sim sequel! The Azzameens vs. Viraxos saga must continue forth.
I need Day of the Tentacle 2: Purple Tentacle's Revenge!
Plus we had Crusader: No Remorse, Crusader: No Regret, and we'll never have Crusader: No Return.