Imagine the wolf sequence from Twilight Princess, give the wolf a magic paint brush, and expand that sequence out to a full length game. That's Okami. Well, sort of. Okami definitely has it's own unique qualities, like the hand-painted Japanese art style, deep combat system, and creative character design, but the Zelda influences simply can't go unnoticed.
Amaterasu, the game's white wolf protagonist, travels around the world, helping NPCs, battling hordes of dark spirits, and delving into dungeons as she attempts to bring life back to the cursed land. The way you earn new powers by meeting with mystical figures throughout your journey is reminiscent of the Zelda titles, and Ami even has an annoying, talkative little companion that will clue you in to the next step in your quest.